DegronMD

Uniprot ID: Q8N2M8

Source protein: CLK4-associating serine/arginine rich protein

Source gene: CLASRP

Class: DEG_APCC_DBOX_1

Location: 82:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8672

ASA_SCORE: 42.4667

COIL: 0.5503

CONS_SCORE: 0.7771

DSS_SCORE: 0.3492

HELIX: 0.3591

FCONS_SCORE: 1.2643

RIG_SCORE: 0.7622

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R83H	TCGA-CG-4306	STAD	TCGA	VRAHLDHIP	DEG_APCC_DBOX_1	0.8244
p.R83H	DO38567	STAD	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	0.8244
p.D78G	TCGA-CR-7379	HNSC	TCGA	VRAHLDHIP	DEG_APCC_DBOX_1	0.2222
p.D78G	DO14174	HNSC	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	0.2222
p.T99I	TCGA-FI-A2F4	UCEC	TCGA	VRAHLDHIP	DEG_APCC_DBOX_1	0.0833
p.T99I	DO43434	UCEC	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	0.0833
p.H88D	DO222717	ESCA	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	0.6577
p.R79Q	DO228359	LICA	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	0.25
p.D72Y	DO229032	LICA	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	0.0556
p.P95S	SIDM00483	Esophageal Carcinoma	GDSC	VRAHLDHIP	DEG_APCC_DBOX_1	0.1944
p.P95S	SK-GT-4	oesophagus	COSMIC	VRAHLDHIP	DEG_APCC_DBOX_1	0.1944
p.P94H	SIDM00220	Ovarian Carcinoma	GDSC	VRAHLDHIP	DEG_APCC_DBOX_1	0.2222
p.P94H	ACH-000962	Ovarian Cancer	CCLE	VRAHLDHIP	DEG_APCC_DBOX_1	0.2222
p.P94H	ACH-001145	Ovarian Cancer	CCLE	VRAHLDHIP	DEG_APCC_DBOX_1	0.2222
p.P94H	OC-314	ovary	COSMIC	VRAHLDHIP	DEG_APCC_DBOX_1	0.2222
p.E90V	SK-UT-1	soft_tissue	COSMIC	VRAHLDHIP	DEG_APCC_DBOX_1	0.7693

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2M8	CLK4-associating serine/arginine rich protein	DEG_APCC_DBOX_1	82:90	VRAHLDHIP	APC,CDC20,FZR1	0.8672	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons