DegronMD - Q14934(NFATC4)

FUNCTION: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:7749981, PubMed:11514544, PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18668201, PubMed:25663301). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:7749981, PubMed:18668201, PubMed:18347059). Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G41E	TCGA-21-1079	LUSC	TCGA	PPPY	ITCH	51:54	Mutation rewiring degron network	0.0556
p.G41E	DO26846	LUSC	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.0556
p.P53T	TCGA-33-4566	LUSC	TCGA	PPPY	ITCH	51:54	Mutation altering degron motif	0.5919
p.P53T	DO26790	LUSC	ICGC	PPPY	ITCH	51:54	Mutation altering degron motif	0.5919
p.R738C	TCGA-A6-2686	COAD	TCGA	PPLY	ITCH	746:749	Mutation rewiring degron network	0.1111
p.P656S	TCGA-AJ-A3BG	UCEC	TCGA	TLTLTVPEY	DEG_COP1_1	645:653	Mutation substituting flanking lysine	0.3611
p.F746C	TCGA-B0-5691	KIRC	TCGA	PPLY	ITCH	746:749	Mutation altering degron motif	0.7108
p.P649H	TCGA-BQ-7059	KIRP	TCGA	TLTLTVPEY	DEG_COP1_1	645:653	Mutation altering degron motif	0.7694
p.G46V	TCGA-BR-8284	STAD	TCGA	PPPY	ITCH	51:54	Mutation rewiring degron network	0.1944
p.G46V	DO38491	STAD	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.1944
p.R662I	TCGA-CN-6994	HNSC	TCGA	TLTLTVPEY	DEG_COP1_1	645:653	Mutation rewiring degron network	0.0833
p.S644L	TCGA-CU-A3YL	BLCA	TCGA	TLTLTVPEY	DEG_COP1_1	645:653	Mutation rewiring degron network	0.3056
p.R738H	TCGA-D1-A0ZS	UCEC	TCGA	PPLY	ITCH	746:749	Mutation rewiring degron network	0.1111
p.R738H	SIDM00150	Colorectal Carcinoma	GDSC	PPLY	ITCH	746:749	Mutation rewiring degron network	0.1111
p.R738H	ACH-000969	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	746:749	Mutation rewiring degron network	0.1111
p.R738H	KM12	large intestine	COSMIC	PPLY	ITCH	746:749	Mutation rewiring degron network	0.1111
p.P757L	TCGA-D7-6520	STAD	TCGA	PPSY	ITCH	755:758	Mutation altering degron motif	0.7582
p.S185C	TCGA-EK-A2R8	CESC	TCGA	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.P755S	TCGA-EO-A22X	UCEC	TCGA	PPSY	ITCH	755:758	Mutation altering degron motif	0.6752
p.P177S	TCGA-IB-7651	PAAD	TCGA	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2778
p.Q642H	TCGA-IB-7651	PAAD	TCGA	TLTLTVPEY	DEG_COP1_1	645:653	Mutation rewiring degron network	0.25
p.S770L	DO51607	CESC	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.25
p.W170L	DO51634	CESC	ICGC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation blocking phosphorylation signal	0.75
p.P767L	DO227984	COCA	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.7582
p.P181Q	DO223016	ESCA	ICGC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1667
p.P758T	DO50002	HNSC	ICGC	PPSY	ITCH	755:758	Mutation altering degron motif	0.7031
p.D761Y	DO228948	LICA	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.3056
p.D761Y	DO228948	LICA	ICGC	PPSY	ITCH	755:758	Mutation rewiring degron network	0.25
p.G776V	DO228948	LICA	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.0833
p.G772S	DO50889	LICA	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation blocking phosphorylation signal	0.6389
p.E765K	DO22905	LIHC	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.7022
p.E765K	DO223918	LIHC	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.7022
p.P755L	DO52330	LIHC	ICGC	PPSY	ITCH	755:758	Mutation altering degron motif	0.7582
p.C180R	DO48682	LIRI	ICGC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.P56S	DO25927	LUAD	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2778
p.G774C	DO231104	LUSC	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.1389
p.K648R	DO232852	NACA	ICGC	TLTLTVPEY	DEG_COP1_1	645:653	Mutation altering degron motif	0.7237
p.D172G	DO232761	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7198
p.H759Y	DO229459	SKCA	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.25
p.H759Y	DO229459	SKCA	ICGC	PPLY	ITCH	746:749	Mutation rewiring degron network	0.0556
p.H759Y	DO229459	SKCA	ICGC	PPSY	ITCH	755:758	Mutation rewiring degron network	0.3056
p.L644M	DO37523	SKCM	ICGC	TLTLTVPEY	DEG_COP1_1	645:653	Mutation rewiring degron network	0.3056
p.P753H	DO37794	SKCM	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.0833
p.P753H	DO37794	SKCM	ICGC	PPLY	ITCH	746:749	Mutation rewiring degron network	0.2222
p.P753H	DO37794	SKCM	ICGC	PPSY	ITCH	755:758	Mutation rewiring degron network	0.2778
p.L769I	DO50279	SKCM	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.2778
p.G185W	DO47607	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.P645S	DO38427	STAD	ICGC	TLTLTVPEY	DEG_COP1_1	645:653	Mutation altering degron motif	0.6752
p.P645S	DO41764	UCEC	ICGC	TLTLTVPEY	DEG_COP1_1	645:653	Mutation altering degron motif	0.6752
p.C176Y	DO229259	THCA	ICGC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.3056
p.E182G	DO229275	THCA	ICGC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1389
p.A763D	DO41638	UCEC	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.7793
p.S756Y	DO41572	UCEC	ICGC	PPSY	ITCH	755:758	Mutation altering degron motif	0.712
p.R180C	SIDM02013	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.G763S	SIDM00216	Colorectal Carcinoma	GDSC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.6993
p.G763S	ACH-000989	Colon/Colorectal Cancer	CCLE	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.6993
p.G763S	SNU-175	large intestine	COSMIC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.6993
p.G163W	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.G163W	ACH-000929	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.G163W	NCI-H2110	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.S43T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.1111
p.S43T	H513	pleura	COSMIC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.1111
p.P757S	SIDM00900	Non-Cancerous	GDSC	PPSY	ITCH	755:758	Mutation altering degron motif	0.6752
p.L174F	SIDM00673	Breast Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.6981
p.M64K	ACH-001322	Sarcoma	CCLE	PPPY	ITCH	51:54	Mutation rewiring degron network	0.0556
p.A61T	ACH-001786	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	51:54	Mutation rewiring degron network	0.1389
p.P177L	ACH-001982	Metastasis	CCLE	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2778
p.D172N	NCI-H630	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.6932
p.P181H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1667
p.R660Q	HEC-1	endometrium	COSMIC	TLTLTVPEY	DEG_COP1_1	645:653	Mutation rewiring degron network	0.1389
p.S162N	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.P752L	COLO-792	skin	COSMIC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.0556
p.P752L	COLO-792	skin	COSMIC	PPLY	ITCH	746:749	Mutation rewiring degron network	0.25
p.P752L	COLO-792	skin	COSMIC	PPSY	ITCH	755:758	Mutation rewiring degron network	0.25
p.A53D	RCC-JW	kidney	COSMIC	PPPY	ITCH	51:54	Mutation altering degron motif	0.7793
p.S174N	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7069
p.P183S	KYSE-140	oesophagus	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.P650L	COLO-792	skin	COSMIC	TLTLTVPEY	DEG_COP1_1	645:653	Mutation altering degron motif	0.7582
p.R663H	KM12	large intestine	COSMIC	TLTLTVPEY	DEG_COP1_1	645:653	Mutation rewiring degron network	0.0556
p.D184N	NCI-H630	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.P750L	NCI-H1694	lung	COSMIC	PPLY	ITCH	746:749	Mutation rewiring degron network	0.3056
p.P750L	NCI-H1694	lung	COSMIC	PPSY	ITCH	755:758	Mutation rewiring degron network	0.1944
p.F775L	KYM-1	soft tissue	COSMIC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.1111
p.A53T	MZ7-mel	skin	COSMIC	PPPY	ITCH	51:54	Mutation altering degron motif	0.7139
p.A59V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.1944
p.P773H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation rewiring degron network	0.1667
p.G174R	NCI-H2135	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7568

Kaplan plot for NFATC4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFATC4

UniProt ID: Q14934

Entrez ID: 4776

Protein name: Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NFATC4 in