DegronMD - Q14934(NFATC4)

FUNCTION: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:7749981, PubMed:11514544, PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18668201, PubM... FUNCTION: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:7749981, PubMed:11514544, PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18668201, PubMed:25663301). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:7749981, PubMed:18668201, PubMed:18347059). Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. View more >>

GO - Biological processes (BP): brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; branching involved in blood vessel morphogenesis [GO:0001569]; calcineurin-NFAT signaling cascade [GO:0033173]; cellular respiration [GO:0045333]; cellular response to lithium ion [GO:0071285]; cellular response to UV [GO:003... View more >>

GO - Molecular function (MF): DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; peroxisome proliferator activated receptor binding [GO:0042975]; RNA polymerase II cis-regulatory region sequence-specific DNA bi... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A763D	DO41638	UCEC	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.7793
p.A53D	RCC-JW	kidney	COSMIC	PPPY	ITCH	51:54	Mutation altering degron motif	0.7793
p.P649H	TCGA-BQ-7059	KIRP	TCGA	TLTLTVPEY	DEG_COP1_1	645:653	Mutation altering degron motif	0.7694
p.P757L	TCGA-D7-6520	STAD	TCGA	PPSY	ITCH	755:758	Mutation altering degron motif	0.7582
p.P767L	DO227984	COCA	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.7582
p.P755L	DO52330	LIHC	ICGC	PPSY	ITCH	755:758	Mutation altering degron motif	0.7582
p.P650L	COLO-792	skin	COSMIC	TLTLTVPEY	DEG_COP1_1	645:653	Mutation altering degron motif	0.7582
p.G174R	NCI-H2135	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7568
p.W170L	DO51634	CESC	ICGC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation blocking phosphorylation signal	0.75
p.K648R	DO232852	NACA	ICGC	TLTLTVPEY	DEG_COP1_1	645:653	Mutation altering degron motif	0.7237
p.D172G	DO232761	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7198
p.A53T	MZ7-mel	skin	COSMIC	PPPY	ITCH	51:54	Mutation altering degron motif	0.7139
p.S756Y	DO41572	UCEC	ICGC	PPSY	ITCH	755:758	Mutation altering degron motif	0.712
p.F746C	TCGA-B0-5691	KIRC	TCGA	PPLY	ITCH	746:749	Mutation altering degron motif	0.7108
p.S174N	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7069
p.P758T	DO50002	HNSC	ICGC	PPSY	ITCH	755:758	Mutation altering degron motif	0.7031
p.E765K	DO22905	LIHC	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.7022
p.E765K	DO223918	LIHC	ICGC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.7022
p.G763S	SIDM00216	Colorectal Carcinoma	GDSC	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.6993
p.G763S	ACH-000989	Colon/Colorectal Cancer	CCLE	LRMFPE	LIG_APCC_ABBA_1	762:767	Mutation altering degron motif	0.6993

Showing 1 to 20 of 87 entries

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Kaplan plot for NFATC4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFATC4

UniProt ID: Q14934

Entrez ID: 4776

Protein name: Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFATC4 in