DegronMD

Uniprot ID: Q14934

Source protein: Nuclear factor of activated T-cells, cytoplasmic 4

Source gene: NFATC4

Class: LIG_APCC_ABBA_1

Location: 762:767

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9898

ASA_SCORE: 103.15

COIL: 0.9103

CONS_SCORE: 0.2893

DSS_SCORE: 0.6027

HELIX: 0.0318

FCONS_SCORE: 0.7838

RIG_SCORE: 0.7041

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S770L	DO51607	CESC	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.25
p.P767L	DO227984	COCA	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.7582
p.D761Y	DO228948	LICA	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.3056
p.G776V	DO228948	LICA	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.0833
p.G772S	DO50889	LICA	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.6389
p.E765K	DO22905	LIHC	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.7022
p.E765K	DO223918	LIHC	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.7022
p.G774C	DO231104	LUSC	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.1389
p.H759Y	DO229459	SKCA	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.25
p.P753H	DO37794	SKCM	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.0833
p.L769I	DO50279	SKCM	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.2778
p.A763D	DO41638	UCEC	ICGC	LRMFPE	LIG_APCC_ABBA_1	0.7793
p.G763S	SIDM00216	Colorectal Carcinoma	GDSC	LRMFPE	LIG_APCC_ABBA_1	0.6993
p.G763S	ACH-000989	Colon/Colorectal Cancer	CCLE	LRMFPE	LIG_APCC_ABBA_1	0.6993
p.G763S	SNU-175	large_intestine	COSMIC	LRMFPE	LIG_APCC_ABBA_1	0.6993
p.P752L	COLO-792	skin	COSMIC	LRMFPE	LIG_APCC_ABBA_1	0.0556
p.F775L	KYM-1	soft_tissue	COSMIC	LRMFPE	LIG_APCC_ABBA_1	0.1111
p.P773H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRMFPE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	LIG_APCC_ABBA_1	762:767	LRMFPE	APC,CDC20,FZR1	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons