DegronMD

Uniprot ID: Q14934

Source protein: Nuclear factor of activated T-cells, cytoplasmic 4

Source gene: NFATC4

Class: DEG_COP1_1

Location: 645:653

E3 ligase: COP1

DEGRON score: 0.5155

ASA_SCORE: 26.0111

COIL: 0.4219

CONS_SCORE: 0.4718

DSS_SCORE: 0.3478

HELIX: 0.0159

FCONS_SCORE: 1.0631

RIG_SCORE: 0.8353

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P656S	TCGA-AJ-A3BG	UCEC	TCGA	TLTLTVPEY	DEG_COP1_1	0.3611
p.P649H	TCGA-BQ-7059	KIRP	TCGA	TLTLTVPEY	DEG_COP1_1	0.7694
p.R662I	TCGA-CN-6994	HNSC	TCGA	TLTLTVPEY	DEG_COP1_1	0.0833
p.S644L	TCGA-CU-A3YL	BLCA	TCGA	TLTLTVPEY	DEG_COP1_1	0.3056
p.Q642H	TCGA-IB-7651	PAAD	TCGA	TLTLTVPEY	DEG_COP1_1	0.25
p.K648R	DO232852	NACA	ICGC	TLTLTVPEY	DEG_COP1_1	0.7237
p.L644M	DO37523	SKCM	ICGC	TLTLTVPEY	DEG_COP1_1	0.3056
p.P645S	DO38427	STAD	ICGC	TLTLTVPEY	DEG_COP1_1	0.6752
p.P645S	DO41764	UCEC	ICGC	TLTLTVPEY	DEG_COP1_1	0.6752
p.R660Q	HEC-1	endometrium	COSMIC	TLTLTVPEY	DEG_COP1_1	0.1389
p.P650L	COLO-792	skin	COSMIC	TLTLTVPEY	DEG_COP1_1	0.7582
p.R663H	KM12	large_intestine	COSMIC	TLTLTVPEY	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	DEG_COP1_1	645:653	TLTLTVPEY	COP1	0.5155	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons