DegronMD - Q9UBP4(DKK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A81T	TCGA-AJ-A3BH	UCEC	TCGA	PPSY	ITCH	91:94	Mutation rewiring degron network	0.0556
p.A81T	DO41638	UCEC	ICGC	PPSY	ITCH	91:94	Mutation rewiring degron network	0.0556
p.R318H	TCGA-AP-A059	UCEC	TCGA	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.8244
p.R318H	TCGA-CM-6171	COAD	TCGA	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.8244
p.R318H	SNU-175	large intestine	COSMIC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.8244
p.D101N	TCGA-AX-A0J1	UCEC	TCGA	PPSY	ITCH	91:94	Mutation rewiring degron network	0.1389
p.D101N	DO41199	UCEC	ICGC	PPSY	ITCH	91:94	Mutation rewiring degron network	0.1389
p.P92L	TCGA-BF-A5EO	SKCM	TCGA	PPSY	ITCH	91:94	Mutation altering degron motif	0.7582
p.P92L	DO219450	SKCM	ICGC	PPSY	ITCH	91:94	Mutation altering degron motif	0.7582
p.L87P	TCGA-BG-A221	UCEC	TCGA	PPSY	ITCH	91:94	Mutation rewiring degron network	0.2222
p.L87P	DO42384	UCEC	ICGC	PPSY	ITCH	91:94	Mutation rewiring degron network	0.2222
p.T98P	TCGA-DK-A6AW	BLCA	TCGA	PPSY	ITCH	91:94	Mutation rewiring degron network	0.2222
p.T98P	DO48566	BLCA	ICGC	PPSY	ITCH	91:94	Mutation rewiring degron network	0.2222
p.S93N	TCGA-E2-A14R	BRCA	TCGA	PPSY	ITCH	91:94	Mutation altering degron motif	0.5958
p.S93N	DO3822	BRCA	ICGC	PPSY	ITCH	91:94	Mutation altering degron motif	0.5958
p.E315K	TCGA-EE-A2GC	SKCM	TCGA	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.2778
p.E315K	DO37839	SKCM	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.2778
p.T100K	DO227802	COCA	ICGC	PPSY	ITCH	91:94	Mutation rewiring degron network	0.1667
p.R335G	DO229010	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.R335G	DO229013	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.R335G	DO229016	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.R335G	DO229003	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.R335G	DO229005	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.R335G	DO231140	LAML	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.R335G	DO229053	LICA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.0556
p.N86K	DO228948	LICA	ICGC	PPSY	ITCH	91:94	Mutation rewiring degron network	0.1944
p.N86K	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	91:94	Mutation rewiring degron network	0.1944
p.N86K	ACH-000343	Lung Cancer	CCLE	PPSY	ITCH	91:94	Mutation rewiring degron network	0.1944
p.S327R	DO229028	LICA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.2778
p.P309S	DO36675	READ	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1111
p.K103T	SIDM02039	Colorectal Carcinoma	GDSC	PPSY	ITCH	91:94	Mutation substituting flanking lysine	0.1944
p.R332H	SIDM00216	Colorectal Carcinoma	GDSC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1389
p.R332H	ACH-000989	Colon/Colorectal Cancer	CCLE	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1389
p.R332H	SNU-175	large intestine	COSMIC	VRQELEDLE	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1389
p.S93G	SIDM01265	Plasma Cell Myeloma	GDSC	PPSY	ITCH	91:94	Mutation altering degron motif	0.5882
p.S93G	SIDM00969	Ovarian Carcinoma	GDSC	PPSY	ITCH	91:94	Mutation altering degron motif	0.5882
p.S93G	SIDM00844	Burkitt's Lymphoma	GDSC	PPSY	ITCH	91:94	Mutation altering degron motif	0.5882
p.Y94D	SIDM00596	Endometrial Carcinoma	GDSC	PPSY	ITCH	91:94	Mutation altering degron motif	0.7325
p.Y94D	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	91:94	Mutation altering degron motif	0.7325
p.Y94D	HEC-1	endometrium	COSMIC	PPSY	ITCH	91:94	Mutation altering degron motif	0.7325
p.T100I	ACH-000773	Lymphoma	CCLE	PPSY	ITCH	91:94	Mutation rewiring degron network	0.1667
p.P92A	ACH-000975	Lung Cancer	CCLE	PPSY	ITCH	91:94	Mutation altering degron motif	0.7503

Kaplan plot for DKK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DKK3

UniProt ID: Q9UBP4

Entrez ID: 27122

Protein name: Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DKK3 in