DegronMD

Uniprot ID: Q9UBP4

Source protein: Dickkopf-related protein 3

Source gene: DKK3

Class: DEG_APCC_DBOX_1

Location: 317:325

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5938

ASA_SCORE: 78.9222

COIL: 0.1381

CONS_SCORE: 0.4107

DSS_SCORE: 0.4578

HELIX: 0.8609

FCONS_SCORE: 1.273

RIG_SCORE: 0.8132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R318H	TCGA-AP-A059	UCEC	TCGA	VRQELEDLE	DEG_APCC_DBOX_1	0.8244
p.R318H	TCGA-CM-6171	COAD	TCGA	VRQELEDLE	DEG_APCC_DBOX_1	0.8244
p.R318H	SNU-175	large_intestine	COSMIC	VRQELEDLE	DEG_APCC_DBOX_1	0.8244
p.E315K	TCGA-EE-A2GC	SKCM	TCGA	VRQELEDLE	DEG_APCC_DBOX_1	0.2778
p.E315K	DO37839	SKCM	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.2778
p.R335G	DO229010	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.0556
p.R335G	DO229013	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.0556
p.R335G	DO229016	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.0556
p.R335G	DO229003	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.0556
p.R335G	DO229005	COCA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.0556
p.R335G	DO231140	LAML	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.0556
p.R335G	DO229053	LICA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.0556
p.S327R	DO229028	LICA	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.2778
p.P309S	DO36675	READ	ICGC	VRQELEDLE	DEG_APCC_DBOX_1	0.1111
p.R332H	SIDM00216	Colorectal Carcinoma	GDSC	VRQELEDLE	DEG_APCC_DBOX_1	0.1389
p.R332H	ACH-000989	Colon/Colorectal Cancer	CCLE	VRQELEDLE	DEG_APCC_DBOX_1	0.1389
p.R332H	SNU-175	large_intestine	COSMIC	VRQELEDLE	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBP4	Dickkopf-related protein 3	DEG_APCC_DBOX_1	317:325	VRQELEDLE	APC,CDC20,FZR1	0.5938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons