DegronMD - O75110(ATP9A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L465V	TCGA-51-4079	LUSC	TCGA	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.2222
p.A464V	TCGA-55-8506	LUAD	TCGA	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.1944
p.E483K	TCGA-91-6830	LUAD	TCGA	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0833
p.R1034Q	TCGA-AG-A002	READ	TCGA	PPSY	ITCH	1039:1042	Mutation rewiring degron network	0.1944
p.R1034Q	TCGA-AP-A0LM	UCEC	TCGA	PPSY	ITCH	1039:1042	Mutation rewiring degron network	0.1944
p.V460M	TCGA-BR-6852	STAD	TCGA	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0833
p.I463T	TCGA-D1-A0ZS	UCEC	TCGA	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.1667
p.N476K	TCGA-DD-A4NI	LIHC	TCGA	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.2778
p.R1036W	TCGA-FI-A2D0	UCEC	TCGA	PPSY	ITCH	1039:1042	Mutation rewiring degron network	0.25
p.R1036L	TCGA-GN-A265	SKCM	TCGA	PPSY	ITCH	1039:1042	Mutation rewiring degron network	0.25
p.A482D	TCGA-GN-A26C	SKCM	TCGA	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.1111
p.Q476K	DO1937	BRCA	ICGC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.2778
p.R461Q	DO227531	PACA	ICGC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation substituting flanking lysine	0.2222
p.A466T	DO219784	UCEC	ICGC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.25
p.R461W	DO219771	UCEC	ICGC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation substituting flanking lysine	0.2222
p.R481H	DO52428	UCEC	ICGC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.1389
p.K467N	DO41133	UCEC	ICGC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.2778
p.T470A	SIDM02033	Colorectal Carcinoma	GDSC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation altering degron motif	0.7139
p.A484S	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0556
p.A484S	HCC-366	lung	COSMIC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0556
p.E483D	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0833
p.E483D	ACH-000840	Lung Cancer	CCLE	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0833
p.E483D	HCC-366	lung	COSMIC	VTPVYE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0833

Kaplan plot for ATP9A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP9A

UniProt ID: O75110

Entrez ID: 10079

Protein name: Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP9A in