DegronMD

Uniprot ID: O75110

Source protein: Probable phospholipid-transporting ATPase IIA

Source gene: ATP9A

Class: DEG_SCF_FBW7_2

Location: 469:474

E3 ligase: FBXW7

DEGRON score: 0.7875

ASA_SCORE: 62.7667

COIL: 0.4358

CONS_SCORE: 0.5983

DSS_SCORE: 0.3133

HELIX: 0.0428

FCONS_SCORE: 1.2563

RIG_SCORE: 0.803

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T470A	SIDM02033	Colorectal Carcinoma	GDSC	VTPVYE	DEG_SCF_FBW7_2	0.7139
p.N476K	TCGA-DD-A4NI	LIHC	TCGA	VTPVYE	DEG_SCF_FBW7_2	0.2778
p.Q476K	DO1937	BRCA	ICGC	VTPVYE	DEG_SCF_FBW7_2	0.2778
p.K467N	DO41133	UCEC	ICGC	VTPVYE	DEG_SCF_FBW7_2	0.2778
p.A466T	DO219784	UCEC	ICGC	VTPVYE	DEG_SCF_FBW7_2	0.25
p.L465V	TCGA-51-4079	LUSC	TCGA	VTPVYE	DEG_SCF_FBW7_2	0.2222
p.R461Q	DO227531	PACA	ICGC	VTPVYE	DEG_SCF_FBW7_2	0.2222
p.R461W	DO219771	UCEC	ICGC	VTPVYE	DEG_SCF_FBW7_2	0.2222
p.A464V	TCGA-55-8506	LUAD	TCGA	VTPVYE	DEG_SCF_FBW7_2	0.1944
p.I463T	TCGA-D1-A0ZS	UCEC	TCGA	VTPVYE	DEG_SCF_FBW7_2	0.1667
p.R481H	DO52428	UCEC	ICGC	VTPVYE	DEG_SCF_FBW7_2	0.1389
p.A482D	TCGA-GN-A26C	SKCM	TCGA	VTPVYE	DEG_SCF_FBW7_2	0.1111
p.E483K	TCGA-91-6830	LUAD	TCGA	VTPVYE	DEG_SCF_FBW7_2	0.0833
p.V460M	TCGA-BR-6852	STAD	TCGA	VTPVYE	DEG_SCF_FBW7_2	0.0833
p.E483D	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VTPVYE	DEG_SCF_FBW7_2	0.0833
p.E483D	ACH-000840	Lung Cancer	CCLE	VTPVYE	DEG_SCF_FBW7_2	0.0833
p.E483D	HCC-366	lung	COSMIC	VTPVYE	DEG_SCF_FBW7_2	0.0833
p.A484S	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VTPVYE	DEG_SCF_FBW7_2	0.0556
p.A484S	HCC-366	lung	COSMIC	VTPVYE	DEG_SCF_FBW7_2	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75110	Probable phospholipid-transporting ATPase IIA	DEG_SCF_FBW7_2	469:474	VTPVYE	FBXW7	0.7875	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons