DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: ITCH

Location: 53:56

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9339

ASA_SCORE: 77.975

COIL: 0.918

CONS_SCORE: 0.5085

DSS_SCORE: 0.2805

HELIX: 0.0582

FCONS_SCORE: 0.7713

RIG_SCORE: 0.718

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y56N	SIDM00217	Colorectal Carcinoma	GDSC	PPSY	ITCH	0.7059
p.Y56N	SNU-1040	large_intestine	COSMIC	PPSY	ITCH	0.7059
p.P53T	TCGA-78-7539	LUAD	TCGA	PPSY	ITCH	0.7031
p.P53T	DO26210	LUAD	ICGC	PPSY	ITCH	0.7031
p.N57I	DO225228	BRCA	ICGC	PPSY	ITCH	0.3056
p.L52M	DO232000	LICA	ICGC	PPSY	ITCH	0.3056
p.G51E	MEL-JUSO	skin	COSMIC	PPSY	ITCH	0.2778
p.M49I	SIDM00665	Gastric Carcinoma	GDSC	PPSY	ITCH	0.2222
p.M49I	ACH-000616	Gastric Cancer	CCLE	PPSY	ITCH	0.2222
p.M49I	Hs746T	stomach	COSMIC	PPSY	ITCH	0.2222
p.T48M	DO227657	COCA	ICGC	PPSY	ITCH	0.1944
p.T48M	SIDM02049	Pancreatic Carcinoma	GDSC	PPSY	ITCH	0.1944
p.V62G	SNU-182	liver	COSMIC	PPSY	ITCH	0.1667
p.V62G	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	PPSY	ITCH	0.1667
p.V62G	SNU-81	large_intestine	COSMIC	PPSY	ITCH	0.1667
p.R63H	TCGA-AP-A0LM	UCEC	TCGA	PPSY	ITCH	0.1389
p.R63H	TCGA-AP-A1DK	UCEC	TCGA	PPSY	ITCH	0.1389
p.R63H	DO43306	UCEC	ICGC	PPSY	ITCH	0.1389
p.R63H	DO42033	UCEC	ICGC	PPSY	ITCH	0.1389
p.R63C	TCGA-AZ-4315	COAD	TCGA	PPSY	ITCH	0.1389
p.R63C	DO8842	COAD	ICGC	PPSY	ITCH	0.1389
p.R63C	SIDM02039	Colorectal Carcinoma	GDSC	PPSY	ITCH	0.1389
p.G63C	NCI-H650	lung	COSMIC	PPSY	ITCH	0.1389

Showing 1 to 23 of 23 entries

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Drug responses associated with VCAN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPSY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5R6	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	ITCH	587:590	PPSY	ITCH,NEDD4	0.737	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	ITCH	459:462	PPSY	ITCH,NEDD4	0.9751	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	415:418	PPSY	ITCH,NEDD4	0.9903	More...
Q96B67	Arrestin domain-containing protein 3	ITCH	346:349	PPSY	ITCH,NEDD4	0.77	More...
Q96J65	ATP-binding cassette sub-family C member 12	ITCH	420:423	PPSY	ITCH,NEDD4	0.6228	More...
Q8N2M8	CLK4-associating serine/arginine rich protein	ITCH	286:289	PPSY	ITCH,NEDD4	0.9968	More...
A6NKD9	Coiled-coil domain-containing protein 85C	ITCH	316:319	PPSY	ITCH,NEDD4	0.9875	More...
Q99715	Collagen alpha-1	ITCH	2574:2577	PPSY	ITCH,NEDD4	0.6822	More...
Q96EP5	DAZ-associated protein 1	ITCH	370:373	PPSY	ITCH,NEDD4	0.9278	More...
Q9H7D0	Dedicator of cytokinesis protein 5	ITCH	1438:1441	PPSY	ITCH,NEDD4	0.5355	More...
O94850	Dendrin	ITCH	200:203	PPSY	ITCH,NEDD4	0.8751	More...
O94850	Dendrin	ITCH	230:233	PPSY	ITCH,NEDD4	0.9726	More...
Q9UBP4	Dickkopf-related protein 3	ITCH	91:94	PPSY	ITCH,NEDD4	0.9656	More...
Q9Y5R6	Doublesex- and mab-3-related transcription factor 1	ITCH	296:299	PPSY	ITCH,NEDD4	0.7856	More...
P11161	E3 SUMO-protein ligase EGR2	ITCH	205:208	PPSY	ITCH,NEDD4	0.9358	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	ITCH	156:159	PPSY	ITCH,NEDD4	0.9269	More...
Q9NT22	EMILIN-3	ITCH	160:163	PPSY	ITCH,NEDD4	0.9466	More...
Q9NRM1	Enamelin	ITCH	853:856	PPSY	ITCH,NEDD4	0.9682	More...
Q14511	Enhancer of filamentation 1	ITCH	109:112	PPSY	ITCH,NEDD4	0.9998	More...
Q6NXG1	Epithelial splicing regulatory protein 1	ITCH	554:557	PPSY	ITCH,NEDD4	0.6605	More...
P19235	Erythropoietin receptor	ITCH	501:504	PPSY	ITCH,NEDD4	0.9994	More...
Q53EP0	Fibronectin type III domain-containing protein 3B	ITCH	110:113	PPSY	ITCH,NEDD4	0.9629	More...
Q5HY92	Fidgetin	ITCH	401:404	PPSY	ITCH,NEDD4	0.9941	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	ITCH	206:209	PPSY	ITCH,NEDD4	0.9258	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	714:717	PPSY	ITCH,NEDD4	0.9896	More...

Showing 1 to 25 of 127 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSY

Degron related mutations and impact score

Drug responses associated with VCAN mutations

All proteins holding degron of PPSY