DegronMD - Q9NT22(EMILIN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P158H	TCGA-38-4626	LUAD	TCGA	PPSY	ITCH	160:163	Mutation rewiring degron network	0.2778
p.P158H	DO24447	LUAD	ICGC	PPSY	ITCH	160:163	Mutation rewiring degron network	0.2778
p.L644I	TCGA-51-4080	LUSC	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.0556
p.L644I	DO26441	LUSC	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.0556
p.R655C	TCGA-AJ-A3EK	UCEC	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation altering degron motif	0.8301
p.R655C	TCGA-AX-A3FS	UCEC	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation altering degron motif	0.8301
p.R655C	DO40879	UCEC	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation altering degron motif	0.8301
p.R655C	DO41584	UCEC	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation altering degron motif	0.8301
p.L661F	TCGA-CK-5913	COAD	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation altering degron motif	0.6981
p.L661F	DO8826	COAD	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation altering degron motif	0.6981
p.S162F	TCGA-EB-A4XL	SKCM	TCGA	PPSY	ITCH	160:163	Mutation altering degron motif	0.6871
p.S162F	DO47401	SKCM	ICGC	PPSY	ITCH	160:163	Mutation altering degron motif	0.6871
p.V665M	TCGA-R6-A8W8	ESCA	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.25
p.S164R	DO229029	LICA	ICGC	PPSY	ITCH	160:163	Mutation rewiring degron network	0.3056
p.Q650K	DO229034	LICA	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.2222
p.P170L	DO231730	LINC	ICGC	PPSY	ITCH	160:163	Mutation rewiring degron network	0.1389
p.V651G	DO219881	SKCA	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.25
p.V651G	ACH-002083	Neuroblastoma	CCLE	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.25
p.P161L	DO229259	THCA	ICGC	PPSY	ITCH	160:163	Mutation altering degron motif	0.7582
p.G647D	DO229268	THCA	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.1389
p.P156S	DO229272	THCA	ICGC	PPSY	ITCH	160:163	Mutation rewiring degron network	0.2222
p.H648L	SIDM00329	Hodgkin's Lymphoma	GDSC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.1667
p.N653K	SIDM00006	Other Solid Cancers	GDSC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.3056
p.N653K	ACH-001552	Skin Cancer	CCLE	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.3056
p.N653K	MCC26	skin	COSMIC	LRGELEQLK	DEG_APCC_DBOX_1	654:662	Mutation rewiring degron network	0.3056
p.P158T	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	PPSY	ITCH	160:163	Mutation rewiring degron network	0.2778
p.P158T	ACH-000727	Lung Cancer	CCLE	PPSY	ITCH	160:163	Mutation rewiring degron network	0.2778
p.P158T	NCI-H2066	lung	COSMIC	PPSY	ITCH	160:163	Mutation rewiring degron network	0.2778
p.G157V	ACH-001568	Skin Cancer	CCLE	PPSY	ITCH	160:163	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EMILIN3

UniProt ID: Q9NT22

Entrez ID: 90187

Protein name: EMILIN-3 (EMILIN-5) (Elastin microfibril interface-located protein 3) (Elastin microfibril interfacer 3) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EMILIN3 in