DegronMD

Uniprot ID: Q9NT22

Source protein: EMILIN-3

Source gene: EMILIN3

Class: DEG_APCC_DBOX_1

Location: 654:662

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9082

ASA_SCORE: 100.1333

COIL: 0.0278

CONS_SCORE: 0.6821

DSS_SCORE: 0.2763

HELIX: 0.9733

FCONS_SCORE: 1.305

RIG_SCORE: 0.7764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L644I	TCGA-51-4080	LUSC	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	0.0556
p.L644I	DO26441	LUSC	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	0.0556
p.R655C	TCGA-AJ-A3EK	UCEC	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	0.8301
p.R655C	TCGA-AX-A3FS	UCEC	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	0.8301
p.R655C	DO40879	UCEC	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	0.8301
p.R655C	DO41584	UCEC	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	0.8301
p.L661F	TCGA-CK-5913	COAD	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	0.6981
p.L661F	DO8826	COAD	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	0.6981
p.V665M	TCGA-R6-A8W8	ESCA	TCGA	LRGELEQLK	DEG_APCC_DBOX_1	0.25
p.Q650K	DO229034	LICA	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	0.2222
p.V651G	DO219881	SKCA	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	0.25
p.V651G	ACH-002083	Neuroblastoma	CCLE	LRGELEQLK	DEG_APCC_DBOX_1	0.25
p.G647D	DO229268	THCA	ICGC	LRGELEQLK	DEG_APCC_DBOX_1	0.1389
p.H648L	SIDM00329	Hodgkin's Lymphoma	GDSC	LRGELEQLK	DEG_APCC_DBOX_1	0.1667
p.N653K	SIDM00006	Other Solid Cancers	GDSC	LRGELEQLK	DEG_APCC_DBOX_1	0.3056
p.N653K	ACH-001552	Skin Cancer	CCLE	LRGELEQLK	DEG_APCC_DBOX_1	0.3056
p.N653K	MCC26	skin	COSMIC	LRGELEQLK	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NT22	EMILIN-3	DEG_APCC_DBOX_1	654:662	LRGELEQLK	APC,CDC20,FZR1	0.9082	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons