DegronMD - Q9Y5R6(DMRT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A321E	TCGA-04-1369	OV	TCGA	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation rewiring degron network	0.0556
p.A321E	DO28183	OV	ICGC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation rewiring degron network	0.0556
p.S338L	TCGA-05-4424	LUAD	TCGA	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation rewiring degron network	0.2778
p.S338L	DO23672	LUAD	ICGC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation rewiring degron network	0.2778
p.H291Y	TCGA-13-0888	OV	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1944
p.H291Y	DO30420	OV	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1944
p.E355K	TCGA-33-AASL	LUSC	TCGA	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation rewiring degron network	0.0556
p.E355K	DO219133	LUSC	ICGC	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation rewiring degron network	0.0556
p.V365A	TCGA-3M-AB46	STAD	TCGA	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation altering degron motif	0.6936
p.V365A	DO222326	STAD	ICGC	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation altering degron motif	0.6936
p.V304M	TCGA-4L-AA1F	PRAD	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1944
p.V304M	DO219247	PRAD	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1944
p.V304M	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1944
p.F307L	TCGA-63-A5MT	LUSC	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1111
p.F307L	DO219163	LUSC	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1111
p.F307L	SIDM00285	Neuroblastoma	GDSC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1111
p.F307L	CHP-134	autonomic ganglia	COSMIC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1111
p.P356T	TCGA-69-7980	LUAD	TCGA	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation rewiring degron network	0.0833
p.P356T	DO23678	LUAD	ICGC	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation rewiring degron network	0.0833
p.V368F	TCGA-77-8143	LUSC	TCGA	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation altering degron motif	0.5957
p.V368F	DO27247	LUSC	ICGC	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation altering degron motif	0.5957
p.L300P	TCGA-AJ-A8CW	UCEC	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.3056
p.L300P	DO52400	UCEC	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.3056
p.S292Y	TCGA-B5-A0JY	UCEC	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.2222
p.S292Y	DO43041	UCEC	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.2222
p.S292F	TCGA-D3-A1QA	SKCM	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.2222
p.S292F	DO47469	SKCM	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.2222
p.P295L	TCGA-DF-A2KZ	UCEC	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.3056
p.P295L	DO52409	UCEC	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.3056
p.P295L	SIDM00812	Colorectal Carcinoma	GDSC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.3056
p.P295L	SW1417	large intestine	COSMIC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.3056
p.S336F	TCGA-EA-A3HU	CESC	TCGA	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation altering degron motif	0.7982
p.S336F	DO6320	CESC	ICGC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation altering degron motif	0.7982
p.R289K	TCGA-EB-A551	SKCM	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1389
p.R289K	DO47453	SKCM	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.1389
p.T309P	TCGA-EE-A20C	SKCM	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.0556
p.T309P	DO222775	MELA	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.0556
p.T309P	DO47665	SKCM	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.0556
p.A321V	TCGA-EI-6881	READ	TCGA	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation rewiring degron network	0.0556
p.A321V	DO37098	READ	ICGC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation rewiring degron network	0.0556
p.G301D	TCGA-FI-A2D5	UCEC	TCGA	PPSY	ITCH	296:299	Mutation rewiring degron network	0.2778
p.G301D	DO222908	MELA	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.2778
p.G301D	DO41331	UCEC	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.2778
p.V323I	TCGA-RD-A8N9	STAD	TCGA	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation rewiring degron network	0.1111
p.V323I	DO50141	STAD	ICGC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation rewiring degron network	0.1111
p.S332C	TCGA-XF-AAMG	BLCA	TCGA	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation altering degron motif	0.7541
p.S332C	DO219049	BLCA	ICGC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation altering degron motif	0.7541
p.V365I	DO228955	LICA	ICGC	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation altering degron motif	0.5965
p.E355D	DO228974	LICA	ICGC	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation rewiring degron network	0.0556
p.E355D	DO229029	LICA	ICGC	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation rewiring degron network	0.0556
p.F324S	DO45171	LIRI	ICGC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation rewiring degron network	0.1389
p.K346R	DO231049	LUSC	ICGC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation substituting flanking lysine	0.1667
p.K346R	SIDM00773	Non-Cancerous	GDSC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation substituting flanking lysine	0.1667
p.K346R	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation substituting flanking lysine	0.1667
p.K346R	SIDM01117	Small Cell Lung Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation substituting flanking lysine	0.1667
p.K346R	SIDM00529	Breast Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation substituting flanking lysine	0.1667
p.K346R	SIDM00849	Kidney Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation substituting flanking lysine	0.1667
p.K346R	SIDM00774	Breast Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation substituting flanking lysine	0.1667
p.K346R	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation substituting flanking lysine	0.1667
p.E373K	DO220899	MELA	ICGC	VTPVIE	DEG_SCF_FBW7_2	365:370	Mutation rewiring degron network	0.25
p.S298F	DO222731	MELA	ICGC	PPSY	ITCH	296:299	Mutation altering degron motif	0.6871
p.G333D	DO51143	PRAD	ICGC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation altering degron motif	0.7198
p.Y293F	DO51962	PRAD	ICGC	PPSY	ITCH	296:299	Mutation rewiring degron network	0.25
p.D331H	SIDM00999	Bladder Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation altering degron motif	0.7688
p.D331H	639-V	urinary tract	COSMIC	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation altering degron motif	0.7688
p.D331N	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGLVS	DEG_SCF_TRCP1_1	331:336	Mutation altering degron motif	0.6932

Kaplan plot for DMRT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMRT1

UniProt ID: Q9Y5R6

Entrez ID: 1761

Protein name: Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMRT1 in