DegronMD

Uniprot ID: Q9Y5R6

Source protein: Doublesex- and mab-3-related transcription factor 1

Source gene: DMRT1

Class: DEG_SCF_FBW7_2

Location: 365:370

E3 ligase: FBXW7

DEGRON score: 0.6689

ASA_SCORE: 83.2

COIL: 0.7085

CONS_SCORE: 0.5308

DSS_SCORE: 0.81

HELIX: 0.0197

FCONS_SCORE: 0.8575

RIG_SCORE: 0.7751

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V365A	TCGA-3M-AB46	STAD	TCGA	VTPVIE	DEG_SCF_FBW7_2	0.6936
p.V365A	DO222326	STAD	ICGC	VTPVIE	DEG_SCF_FBW7_2	0.6936
p.V365I	DO228955	LICA	ICGC	VTPVIE	DEG_SCF_FBW7_2	0.5965
p.V368F	TCGA-77-8143	LUSC	TCGA	VTPVIE	DEG_SCF_FBW7_2	0.5957
p.V368F	DO27247	LUSC	ICGC	VTPVIE	DEG_SCF_FBW7_2	0.5957
p.E373K	DO220899	MELA	ICGC	VTPVIE	DEG_SCF_FBW7_2	0.25
p.P356T	TCGA-69-7980	LUAD	TCGA	VTPVIE	DEG_SCF_FBW7_2	0.0833
p.P356T	DO23678	LUAD	ICGC	VTPVIE	DEG_SCF_FBW7_2	0.0833
p.E355K	TCGA-33-AASL	LUSC	TCGA	VTPVIE	DEG_SCF_FBW7_2	0.0556
p.E355K	DO219133	LUSC	ICGC	VTPVIE	DEG_SCF_FBW7_2	0.0556
p.E355D	DO228974	LICA	ICGC	VTPVIE	DEG_SCF_FBW7_2	0.0556
p.E355D	DO229029	LICA	ICGC	VTPVIE	DEG_SCF_FBW7_2	0.0556

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5R6	Doublesex- and mab-3-related transcription factor 1	DEG_SCF_FBW7_2	365:370	VTPVIE	FBXW7	0.6689	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons