DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGLVS
Uniprot ID:
Q9Y5R6
Source protein:
Doublesex- and mab-3-related transcription factor 1
Source gene:
DMRT1
Class:
DEG_SCF_TRCP1_1
Location:
331:336
E3 ligase:
BTRC
DEGRON score:
0.9465
ASA_SCORE:
68.7333
COIL:
0.8512
CONS_SCORE:
0.6397
DSS_SCORE:
0.5126
HELIX:
0.0797
FCONS_SCORE:
0.9932
RIG_SCORE:
0.6229
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S336F
TCGA-EA-A3HU
CESC
TCGA
DSGLVS
DEG_SCF_TRCP1_1
0.7982
p.S336F
DO6320
CESC
ICGC
DSGLVS
DEG_SCF_TRCP1_1
0.7982
p.D331H
SIDM00999
Bladder Carcinoma
GDSC
DSGLVS
DEG_SCF_TRCP1_1
0.7688
p.D331H
639-V
urinary_tract
COSMIC
DSGLVS
DEG_SCF_TRCP1_1
0.7688
p.S332C
TCGA-XF-AAMG
BLCA
TCGA
DSGLVS
DEG_SCF_TRCP1_1
0.7541
p.S332C
DO219049
BLCA
ICGC
DSGLVS
DEG_SCF_TRCP1_1
0.7541
p.G333D
DO51143
PRAD
ICGC
DSGLVS
DEG_SCF_TRCP1_1
0.7198
p.D331N
ACH-000982
Colon/Colorectal Cancer
CCLE
DSGLVS
DEG_SCF_TRCP1_1
0.6932
p.S338L
TCGA-05-4424
LUAD
TCGA
DSGLVS
DEG_SCF_TRCP1_1
0.2778
p.S338L
DO23672
LUAD
ICGC
DSGLVS
DEG_SCF_TRCP1_1
0.2778
p.K346R
DO231049
LUSC
ICGC
DSGLVS
DEG_SCF_TRCP1_1
0.1667
p.K346R
SIDM00773
Non-Cancerous
GDSC
DSGLVS
DEG_SCF_TRCP1_1
0.1667
p.K346R
SIDM01116
Non-Small Cell Lung Carcinoma
GDSC
DSGLVS
DEG_SCF_TRCP1_1
0.1667
p.K346R
SIDM01117
Small Cell Lung Carcinoma
GDSC
DSGLVS
DEG_SCF_TRCP1_1
0.1667
p.K346R
SIDM00529
Breast Carcinoma
GDSC
DSGLVS
DEG_SCF_TRCP1_1
0.1667
p.K346R
SIDM00849
Kidney Carcinoma
GDSC
DSGLVS
DEG_SCF_TRCP1_1
0.1667
p.K346R
SIDM00774
Breast Carcinoma
GDSC
DSGLVS
DEG_SCF_TRCP1_1
0.1667
p.K346R
SIDM01677
Non-Small Cell Lung Carcinoma
GDSC
DSGLVS
DEG_SCF_TRCP1_1
0.1667
p.F324S
DO45171
LIRI
ICGC
DSGLVS
DEG_SCF_TRCP1_1
0.1389
p.V323I
TCGA-RD-A8N9
STAD
TCGA
DSGLVS
DEG_SCF_TRCP1_1
0.1111
p.V323I
DO50141
STAD
ICGC
DSGLVS
DEG_SCF_TRCP1_1
0.1111
p.A321E
TCGA-04-1369
OV
TCGA
DSGLVS
DEG_SCF_TRCP1_1
0.0556
p.A321E
DO28183
OV
ICGC
DSGLVS
DEG_SCF_TRCP1_1
0.0556
p.A321V
TCGA-EI-6881
READ
TCGA
DSGLVS
DEG_SCF_TRCP1_1
0.0556
p.A321V
DO37098
READ
ICGC
DSGLVS
DEG_SCF_TRCP1_1
0.0556
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Drug responses associated with DMRT1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of DSGLVS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y5R6
Doublesex- and mab-3-related transcription factor 1
DEG_SCF_TRCP1_1
331:336
DSGLVS
BTRC
0.9465
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