DegronMD

Uniprot ID: Q9Y5R6

Source protein: Doublesex- and mab-3-related transcription factor 1

Source gene: DMRT1

Class: DEG_SCF_TRCP1_1

Location: 331:336

E3 ligase: BTRC

DEGRON score: 0.9465

ASA_SCORE: 68.7333

COIL: 0.8512

CONS_SCORE: 0.6397

DSS_SCORE: 0.5126

HELIX: 0.0797

FCONS_SCORE: 0.9932

RIG_SCORE: 0.6229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A321E	TCGA-04-1369	OV	TCGA	DSGLVS	DEG_SCF_TRCP1_1	0.0556
p.A321E	DO28183	OV	ICGC	DSGLVS	DEG_SCF_TRCP1_1	0.0556
p.S338L	TCGA-05-4424	LUAD	TCGA	DSGLVS	DEG_SCF_TRCP1_1	0.2778
p.S338L	DO23672	LUAD	ICGC	DSGLVS	DEG_SCF_TRCP1_1	0.2778
p.S336F	TCGA-EA-A3HU	CESC	TCGA	DSGLVS	DEG_SCF_TRCP1_1	0.7982
p.S336F	DO6320	CESC	ICGC	DSGLVS	DEG_SCF_TRCP1_1	0.7982
p.A321V	TCGA-EI-6881	READ	TCGA	DSGLVS	DEG_SCF_TRCP1_1	0.0556
p.A321V	DO37098	READ	ICGC	DSGLVS	DEG_SCF_TRCP1_1	0.0556
p.V323I	TCGA-RD-A8N9	STAD	TCGA	DSGLVS	DEG_SCF_TRCP1_1	0.1111
p.V323I	DO50141	STAD	ICGC	DSGLVS	DEG_SCF_TRCP1_1	0.1111
p.S332C	TCGA-XF-AAMG	BLCA	TCGA	DSGLVS	DEG_SCF_TRCP1_1	0.7541
p.S332C	DO219049	BLCA	ICGC	DSGLVS	DEG_SCF_TRCP1_1	0.7541
p.F324S	DO45171	LIRI	ICGC	DSGLVS	DEG_SCF_TRCP1_1	0.1389
p.K346R	DO231049	LUSC	ICGC	DSGLVS	DEG_SCF_TRCP1_1	0.1667
p.K346R	SIDM00773	Non-Cancerous	GDSC	DSGLVS	DEG_SCF_TRCP1_1	0.1667
p.K346R	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	0.1667
p.K346R	SIDM01117	Small Cell Lung Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	0.1667
p.K346R	SIDM00529	Breast Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	0.1667
p.K346R	SIDM00849	Kidney Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	0.1667
p.K346R	SIDM00774	Breast Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	0.1667
p.K346R	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	0.1667
p.G333D	DO51143	PRAD	ICGC	DSGLVS	DEG_SCF_TRCP1_1	0.7198
p.D331H	SIDM00999	Bladder Carcinoma	GDSC	DSGLVS	DEG_SCF_TRCP1_1	0.7688
p.D331H	639-V	urinary_tract	COSMIC	DSGLVS	DEG_SCF_TRCP1_1	0.7688
p.D331N	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGLVS	DEG_SCF_TRCP1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5R6	Doublesex- and mab-3-related transcription factor 1	DEG_SCF_TRCP1_1	331:336	DSGLVS	BTRC	0.9465	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGLVS

Degron related mutations and impact score

Drug responses associated with DMRT1 mutations

All proteins holding degron of DSGLVS