DegronMD

Uniprot ID: Q70EL1

Source protein: Inactive ubiquitin carboxyl-terminal hydrolase 54

Source gene: USP54

Class: DEG_SCF_TRCP1_1

Location: 380:386

E3 ligase: BTRC

DEGRON score: 0.9476

ASA_SCORE: 83.3857

COIL: 0.8436

CONS_SCORE: 0.436

DSS_SCORE: 0.6586

HELIX: 0.1134

FCONS_SCORE: 1.0148

RIG_SCORE: 0.5888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I387V	TCGA-21-1077	LUSC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	0.3056
p.R392Q	TCGA-A5-A2K5	UCEC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	0.1667
p.R392Q	TCGA-BS-A0UF	UCEC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	0.1667
p.D394Y	TCGA-AJ-A3EL	UCEC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	0.1111
p.Y371H	TCGA-CG-5728	STAD	TCGA	DSGREPS	DEG_SCF_TRCP1_1	0.0833
p.S372I	TCGA-E6-A1LZ	UCEC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	0.1111
p.N377D	DO48566	BLCA	ICGC	DSGREPS	DEG_SCF_TRCP1_1	0.25
p.P370T	DO228926	LICA	ICGC	DSGREPS	DEG_SCF_TRCP1_1	0.0556
p.P390H	DO228948	LICA	ICGC	DSGREPS	DEG_SCF_TRCP1_1	0.2222
p.D388E	DO229019	LICA	ICGC	DSGREPS	DEG_SCF_TRCP1_1	0.7222
p.G384S	DO41644	UCEC	ICGC	DSGREPS	DEG_SCF_TRCP1_1	0.6993
p.T393I	SIDM00282	Colorectal Carcinoma	GDSC	DSGREPS	DEG_SCF_TRCP1_1	0.1389
p.T393I	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGREPS	DEG_SCF_TRCP1_1	0.1389
p.T393I	CW-2	large_intestine	COSMIC	DSGREPS	DEG_SCF_TRCP1_1	0.1389
p.E384D	SIDM00438	B-Lymphoblastic Leukemia	GDSC	DSGREPS	DEG_SCF_TRCP1_1	0.5647
p.E384D	ACH-002275	Leukemia	CCLE	DSGREPS	DEG_SCF_TRCP1_1	0.5647
p.E384D	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	DSGREPS	DEG_SCF_TRCP1_1	0.5647
p.P375S	SW48	large_intestine	COSMIC	DSGREPS	DEG_SCF_TRCP1_1	0.1944
p.I390T	MFE-319	endometrium	COSMIC	DSGREPS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	DEG_SCF_TRCP1_1	380:386	DSGREPS	BTRC	0.9476	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons