DegronMD

Uniprot ID: Q70EL1

Source protein: Inactive ubiquitin carboxyl-terminal hydrolase 54

Source gene: USP54

Class: LIG_APCC_ABBA_1

Location: 602:607

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9347

ASA_SCORE: 84.1333

COIL: 0.8362

CONS_SCORE: 0.4128

DSS_SCORE: 0.4939

HELIX: 0.1315

FCONS_SCORE: 0.8596

RIG_SCORE: 0.6991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R594S	TCGA-77-8136	LUSC	TCGA	LSPFSE	LIG_APCC_ABBA_1	0.1111
p.R600M	DO223732	CESC	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.2778
p.A599D	DO229025	LICA	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.25
p.Q605H	DO42280	UCEC	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.7582
p.R608Q	DO41331	UCEC	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.3056
p.L602V	SIDM01062	Breast Carcinoma	GDSC	LSPFSE	LIG_APCC_ABBA_1	0.5654
p.L602V	ACH-000643	Breast Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	0.5654
p.L602V	HDQ-P1	breast	COSMIC	LSPFSE	LIG_APCC_ABBA_1	0.5654
p.D592E	ACH-001201	Brain Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10586	Receptor-type tyrosine-protein phosphatase F	LIG_APCC_ABBA_1	379:384	LSPFSE	APC,CDC20,FZR1	0.783	More...
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	LIG_APCC_ABBA_1	602:607	LSPFSE	APC,CDC20,FZR1	0.9347	More...
Q2NL68	Proline and serine-rich protein 3	LIG_APCC_ABBA_1	236:241	LSPFSE	APC,CDC20,FZR1	0.9736	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons