DegronMD

Uniprot ID: P10586

Source protein: Receptor-type tyrosine-protein phosphatase F

Source gene: PTPRF

Class: LIG_APCC_ABBA_1

Location: 379:384

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.783

ASA_SCORE: 49.1333

COIL: 0.7558

CONS_SCORE: 0.495

DSS_SCORE: 0.1232

HELIX: 0.0093

FCONS_SCORE: 1.0424

RIG_SCORE: 0.7962

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G378S	TCGA-63-6202	LUSC	TCGA	LSPFSE	LIG_APCC_ABBA_1	0.3056
p.G378S	DO26560	LUSC	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.3056
p.G378S	SIDM01018	Hodgkin's Lymphoma	GDSC	LSPFSE	LIG_APCC_ABBA_1	0.3056
p.G378S	ACH-000815	Lymphoma	CCLE	LSPFSE	LIG_APCC_ABBA_1	0.3056
p.G378S	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	LSPFSE	LIG_APCC_ABBA_1	0.3056
p.T372A	TCGA-AJ-A23O	UCEC	TCGA	LSPFSE	LIG_APCC_ABBA_1	0.1389
p.T372A	DO43290	UCEC	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.1389
p.R388H	TCGA-AJ-A3BH	UCEC	TCGA	LSPFSE	LIG_APCC_ABBA_1	0.2222
p.R388H	DO41638	UCEC	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.2222
p.S383L	TCGA-EE-A183	SKCM	TCGA	LSPFSE	LIG_APCC_ABBA_1	0.6556
p.S383L	DO37715	SKCM	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.6556
p.R373H	TCGA-HJ-7597	STAD	TCGA	LSPFSE	LIG_APCC_ABBA_1	0.1667
p.R373H	DO234219	ESAD	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.1667
p.R373H	DO38195	STAD	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.1667
p.A370G	TCGA-MF-A522	LUSC	TCGA	LSPFSE	LIG_APCC_ABBA_1	0.0833
p.A370G	DO45526	LUSC	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.0833
p.V389M	TCGA-VQ-A91D	STAD	TCGA	LSPFSE	LIG_APCC_ABBA_1	0.1944
p.V389M	DO51783	STAD	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.1944
p.A370T	DO8360	COAD	ICGC	LSPFSE	LIG_APCC_ABBA_1	0.0833
p.S394T	SIDM00042	Pancreatic Carcinoma	GDSC	LSPFSE	LIG_APCC_ABBA_1	0.5
p.S394T	ACH-002186	Pancreatic Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	0.5
p.S394T	PL4	pancreas	COSMIC	LSPFSE	LIG_APCC_ABBA_1	0.5
p.A391V	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LSPFSE	LIG_APCC_ABBA_1	0.1389
p.A391V	ACH-000886	Lung Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	0.1389
p.A391V	NCI-H2009	lung	COSMIC	LSPFSE	LIG_APCC_ABBA_1	0.1389
p.P381L	ACH-002396	Bone Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	0.6471
p.P381L	Sarc9371	bone	COSMIC	LSPFSE	LIG_APCC_ABBA_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10586	Receptor-type tyrosine-protein phosphatase F	LIG_APCC_ABBA_1	379:384	LSPFSE	APC,CDC20,FZR1	0.783	More...
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	LIG_APCC_ABBA_1	602:607	LSPFSE	APC,CDC20,FZR1	0.9347	More...
Q2NL68	Proline and serine-rich protein 3	LIG_APCC_ABBA_1	236:241	LSPFSE	APC,CDC20,FZR1	0.9736	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSPFSE

Degron related mutations and impact score

Drug responses associated with PTPRF mutations

All proteins holding degron of LSPFSE