DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LSPFSE
Uniprot ID:
Q2NL68
Source protein:
Proline and serine-rich protein 3
Source gene:
PROSER3
Class:
LIG_APCC_ABBA_1
Location:
236:241
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9736
ASA_SCORE:
75.25
COIL:
0.8642
CONS_SCORE:
0.812
DSS_SCORE:
0.5789
HELIX:
0.037
FCONS_SCORE:
0.9975
RIG_SCORE:
0.633
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PROSER3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LSPFSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P10586
Receptor-type tyrosine-protein phosphatase F
LIG_APCC_ABBA_1
379:384
LSPFSE
APC,CDC20,FZR1
0.783
More...
Q70EL1
Inactive ubiquitin carboxyl-terminal hydrolase 54
LIG_APCC_ABBA_1
602:607
LSPFSE
APC,CDC20,FZR1
0.9347
More...
Q2NL68
Proline and serine-rich protein 3
LIG_APCC_ABBA_1
236:241
LSPFSE
APC,CDC20,FZR1
0.9736
More...