DegronMD - P10586(PTPRF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R600S	TCGA-05-4396	LUAD	TCGA	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.2778
p.R600S	DO23838	LUAD	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.2778
p.Y800S	TCGA-50-5072	LUAD	TCGA	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.1111
p.Y800S	DO25967	LUAD	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.1111
p.G378S	TCGA-63-6202	LUSC	TCGA	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.3056
p.G378S	DO26560	LUSC	ICGC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.3056
p.G378S	SIDM01018	Hodgkin's Lymphoma	GDSC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.3056
p.G378S	ACH-000815	Lymphoma	CCLE	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.3056
p.G378S	KM-H2	haematopoietic and lymphoid tissue	COSMIC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.3056
p.R989H	TCGA-A5-A0G2	UCEC	TCGA	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.0556
p.R989H	DO233156	GACA	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.0556
p.R989H	DO41235	UCEC	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.0556
p.E718D	TCGA-AA-3877	COAD	TCGA	TDEDVPSGP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1389
p.E718D	DO7855	COAD	ICGC	TDEDVPSGP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1389
p.P606H	TCGA-AB-2821	LAML	TCGA	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.1111
p.P606H	DO21655	LAML	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.1111
p.T372A	TCGA-AJ-A23O	UCEC	TCGA	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1389
p.T372A	DO43290	UCEC	ICGC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1389
p.R388H	TCGA-AJ-A3BH	UCEC	TCGA	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.2222
p.R388H	DO41638	UCEC	ICGC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.2222
p.D985V	TCGA-B5-A3FA	UCEC	TCGA	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.1667
p.D985V	DO52402	UCEC	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.1667
p.P694L	TCGA-B5-A3FC	UCEC	TCGA	TDEDVPSGP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.0833
p.P694L	DO41871	UCEC	ICGC	TDEDVPSGP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.0833
p.P595A	TCGA-BQ-5876	KIRP	TCGA	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.7503
p.P595A	DO20759	KIRP	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.7503
p.A584V	TCGA-CV-7245	HNSC	TCGA	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.1111
p.A584V	DO14322	HNSC	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.1111
p.D970H	TCGA-CV-7427	HNSC	TCGA	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.3056
p.D970H	DO14286	HNSC	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.3056
p.T983I	TCGA-CV-7568	HNSC	TCGA	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.2222
p.T983I	DO14160	HNSC	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.2222
p.T594A	TCGA-D8-A1XK	BRCA	TCGA	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.825
p.T594A	DO4749	BRCA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.825
p.S383L	TCGA-EE-A183	SKCM	TCGA	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation altering degron motif	0.6556
p.S383L	DO37715	SKCM	ICGC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation altering degron motif	0.6556
p.S794F	TCGA-EE-A2M5	SKCM	TCGA	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S794F	TCGA-EE-A2MD	SKCM	TCGA	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S794F	TCGA-EE-A2MJ	SKCM	TCGA	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S794F	DO222423	MELA	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S794F	DO222434	MELA	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S794F	DO37851	SKCM	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S794F	DO37425	SKCM	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S794F	DO38099	SKCM	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S794F	SIDM00080	Melanoma	GDSC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S794F	SK-MEL-5	skin	COSMIC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.R600H	TCGA-EO-A22U	UCEC	TCGA	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.2778
p.R600H	DO43755	UCEC	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.2778
p.D704N	TCGA-EO-A22U	UCEC	TCGA	TDEDVPSGP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6932
p.D704N	DO43755	UCEC	ICGC	TDEDVPSGP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6932
p.P789Q	TCGA-ER-A19B	SKCM	TCGA	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation altering degron motif	0.7035
p.P789Q	DO47491	SKCM	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation altering degron motif	0.7035
p.G786D	TCGA-FI-A2D5	UCEC	TCGA	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.3056
p.G786D	DO41331	UCEC	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.3056
p.R373H	TCGA-HJ-7597	STAD	TCGA	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1667
p.R373H	DO234219	ESAD	ICGC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1667
p.R373H	DO38195	STAD	ICGC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1667
p.V795I	TCGA-HU-A4GX	STAD	TCGA	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.25
p.V795I	DO47757	STAD	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.25
p.A370G	TCGA-MF-A522	LUSC	TCGA	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.0833
p.A370G	DO45526	LUSC	ICGC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.0833
p.V389M	TCGA-VQ-A91D	STAD	TCGA	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1944
p.V389M	DO51783	STAD	ICGC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1944
p.T792I	DO52610	BOCA	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation altering degron motif	0.7078
p.T792I	ACH-000906	Ovarian Cancer	CCLE	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation altering degron motif	0.7078
p.T792I	ES-2	ovary	COSMIC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation altering degron motif	0.7078
p.A370T	DO8360	COAD	ICGC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.0833
p.G693S	DO230336	COCA	ICGC	TDEDVPSGP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.0556
p.D704Y	DO229029	LICA	ICGC	TDEDVPSGP	DEG_COP1_1	703:711	Mutation altering degron motif	0.7325
p.A584S	DO229026	LICA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.1111
p.A602S	DO229026	LICA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.2222
p.V795F	DO229032	LICA	ICGC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.25
p.P712Q	DO50672	ORCA	ICGC	TDEDVPSGP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.3056
p.V592I	DO51082	PRAD	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.5965
p.V592I	SIDM00343	Glioblastoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.5965
p.V592I	SIDM00027	Kidney Carcinoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.5965
p.V592I	SIDM01101	Neuroblastoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.5965
p.V592I	SIDM00105	Ovarian Carcinoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.5965
p.V592I	SIDM00093	Ovarian Carcinoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.5965
p.A608P	DO229229	THCA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.0556
p.S607P	DO229224	THCA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.0833
p.S607P	DO229234	THCA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation rewiring degron network	0.0833
p.Q965P	SIDM00683	Prostate Carcinoma	GDSC	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.1667
p.S394T	SIDM00042	Pancreatic Carcinoma	GDSC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation blocking phosphorylation signal	0.5
p.S394T	ACH-002186	Pancreatic Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation blocking phosphorylation signal	0.5
p.S394T	PL4	pancreas	COSMIC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation blocking phosphorylation signal	0.5
p.I784V	SIDM00057	Neuroblastoma	GDSC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.25
p.I784V	SIDM00552	Rhabdomyosarcoma	GDSC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.25
p.I784V	KYM-1	soft tissue	COSMIC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.25
p.D985H	SIDM00311	Mesothelioma	GDSC	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.1667
p.D985H	H2810	pleura	COSMIC	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation rewiring degron network	0.1667
p.A391V	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1389
p.A391V	ACH-000886	Lung Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1389
p.A391V	NCI-H2009	lung	COSMIC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation rewiring degron network	0.1389
p.T801I	SIDM00861	Ovarian Carcinoma	GDSC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.0833
p.T801I	ES-2	ovary	COSMIC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.0833
p.S785F	ACH-000730	Skin Cancer	CCLE	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.S785F	SK-MEL-5	skin	COSMIC	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2778
p.P711T	ACH-001628	Ovarian Cancer	CCLE	TDEDVPSGP	DEG_COP1_1	703:711	Mutation altering degron motif	0.7031
p.T783A	ACH-001786	Colon/Colorectal Cancer	CCLE	LTPETT	DEG_SCF_FBW7_1	787:792	Mutation rewiring degron network	0.2222
p.T594S	ACH-001970	Metastasis	CCLE	VFTPTIE	DEG_SCF_FBW7_2	592:598	Mutation altering degron motif	0.8227
p.P381L	ACH-002396	Bone Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation altering degron motif	0.6471
p.P381L	Sarc9371	bone	COSMIC	LSPFSE	LIG_APCC_ABBA_1	379:384	Mutation altering degron motif	0.6471
p.V717G	HCC38	breast	COSMIC	TDEDVPSGP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1667
p.D976H	H2810	pleura	COSMIC	TRFTLTGLK	DEG_APCC_DBOX_1	971:979	Mutation altering degron motif	0.7688

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRF

UniProt ID: P10586

Entrez ID: 5792

Protein name: Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPRF in