DegronMD

Uniprot ID: P10586

Source protein: Receptor-type tyrosine-protein phosphatase F

Source gene: PTPRF

Class: DEG_COP1_1

Location: 703:711

E3 ligase: COP1

DEGRON score: 0.9354

ASA_SCORE: 70.2222

COIL: 0.7696

CONS_SCORE: 0.548

DSS_SCORE: 0.574

HELIX: 0.0222

FCONS_SCORE: 1.2662

RIG_SCORE: 0.6593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E718D	TCGA-AA-3877	COAD	TCGA	TDEDVPSGP	DEG_COP1_1	0.1389
p.E718D	DO7855	COAD	ICGC	TDEDVPSGP	DEG_COP1_1	0.1389
p.P694L	TCGA-B5-A3FC	UCEC	TCGA	TDEDVPSGP	DEG_COP1_1	0.0833
p.P694L	DO41871	UCEC	ICGC	TDEDVPSGP	DEG_COP1_1	0.0833
p.D704N	TCGA-EO-A22U	UCEC	TCGA	TDEDVPSGP	DEG_COP1_1	0.6932
p.D704N	DO43755	UCEC	ICGC	TDEDVPSGP	DEG_COP1_1	0.6932
p.G693S	DO230336	COCA	ICGC	TDEDVPSGP	DEG_COP1_1	0.0556
p.D704Y	DO229029	LICA	ICGC	TDEDVPSGP	DEG_COP1_1	0.7325
p.P712Q	DO50672	ORCA	ICGC	TDEDVPSGP	DEG_COP1_1	0.3056
p.P711T	ACH-001628	Ovarian Cancer	CCLE	TDEDVPSGP	DEG_COP1_1	0.7031
p.V717G	HCC38	breast	COSMIC	TDEDVPSGP	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10586	Receptor-type tyrosine-protein phosphatase F	DEG_COP1_1	703:711	TDEDVPSGP	COP1	0.9354	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons