DegronMD

Uniprot ID: P10586

Source protein: Receptor-type tyrosine-protein phosphatase F

Source gene: PTPRF

Class: DEG_SCF_FBW7_1

Location: 787:792

E3 ligase: FBXW7

DEGRON score: 0.9486

ASA_SCORE: 65.9333

COIL: 0.6758

CONS_SCORE: 0.4385

DSS_SCORE: 0.4006

HELIX: 0.0063

FCONS_SCORE: 1.0578

RIG_SCORE: 0.7463

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y800S	TCGA-50-5072	LUAD	TCGA	LTPETT	DEG_SCF_FBW7_1	0.1111
p.Y800S	DO25967	LUAD	ICGC	LTPETT	DEG_SCF_FBW7_1	0.1111
p.S794F	TCGA-EE-A2M5	SKCM	TCGA	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S794F	TCGA-EE-A2MD	SKCM	TCGA	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S794F	TCGA-EE-A2MJ	SKCM	TCGA	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S794F	DO222423	MELA	ICGC	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S794F	DO222434	MELA	ICGC	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S794F	DO37851	SKCM	ICGC	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S794F	DO37425	SKCM	ICGC	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S794F	DO38099	SKCM	ICGC	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S794F	SIDM00080	Melanoma	GDSC	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S794F	SK-MEL-5	skin	COSMIC	LTPETT	DEG_SCF_FBW7_1	0.2778
p.P789Q	TCGA-ER-A19B	SKCM	TCGA	LTPETT	DEG_SCF_FBW7_1	0.7035
p.P789Q	DO47491	SKCM	ICGC	LTPETT	DEG_SCF_FBW7_1	0.7035
p.G786D	TCGA-FI-A2D5	UCEC	TCGA	LTPETT	DEG_SCF_FBW7_1	0.3056
p.G786D	DO41331	UCEC	ICGC	LTPETT	DEG_SCF_FBW7_1	0.3056
p.V795I	TCGA-HU-A4GX	STAD	TCGA	LTPETT	DEG_SCF_FBW7_1	0.25
p.V795I	DO47757	STAD	ICGC	LTPETT	DEG_SCF_FBW7_1	0.25
p.T792I	DO52610	BOCA	ICGC	LTPETT	DEG_SCF_FBW7_1	0.7078
p.T792I	ACH-000906	Ovarian Cancer	CCLE	LTPETT	DEG_SCF_FBW7_1	0.7078
p.T792I	ES-2	ovary	COSMIC	LTPETT	DEG_SCF_FBW7_1	0.7078
p.V795F	DO229032	LICA	ICGC	LTPETT	DEG_SCF_FBW7_1	0.25
p.I784V	SIDM00057	Neuroblastoma	GDSC	LTPETT	DEG_SCF_FBW7_1	0.25
p.I784V	SIDM00552	Rhabdomyosarcoma	GDSC	LTPETT	DEG_SCF_FBW7_1	0.25
p.I784V	KYM-1	soft_tissue	COSMIC	LTPETT	DEG_SCF_FBW7_1	0.25
p.T801I	SIDM00861	Ovarian Carcinoma	GDSC	LTPETT	DEG_SCF_FBW7_1	0.0833
p.T801I	ES-2	ovary	COSMIC	LTPETT	DEG_SCF_FBW7_1	0.0833
p.S785F	ACH-000730	Skin Cancer	CCLE	LTPETT	DEG_SCF_FBW7_1	0.2778
p.S785F	SK-MEL-5	skin	COSMIC	LTPETT	DEG_SCF_FBW7_1	0.2778
p.T783A	ACH-001786	Colon/Colorectal Cancer	CCLE	LTPETT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPETT

Degron related mutations and impact score

Drug responses associated with PTPRF mutations

All proteins holding degron of LTPETT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10586	Receptor-type tyrosine-protein phosphatase F	DEG_SCF_FBW7_1	787:792	LTPETT	FBXW7	0.9486	More...