DegronMD

Uniprot ID: P10586

Source protein: Receptor-type tyrosine-protein phosphatase F

Source gene: PTPRF

Class: DEG_APCC_DBOX_1

Location: 971:979

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.837

ASA_SCORE: 51.4889

COIL: 0.4334

CONS_SCORE: 0.4061

DSS_SCORE: 0.3248

HELIX: 0.0096

FCONS_SCORE: 0.8694

RIG_SCORE: 0.8395

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R989H	TCGA-A5-A0G2	UCEC	TCGA	TRFTLTGLK	DEG_APCC_DBOX_1	0.0556
p.R989H	DO233156	GACA	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	0.0556
p.R989H	DO41235	UCEC	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	0.0556
p.D985V	TCGA-B5-A3FA	UCEC	TCGA	TRFTLTGLK	DEG_APCC_DBOX_1	0.1667
p.D985V	DO52402	UCEC	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	0.1667
p.D970H	TCGA-CV-7427	HNSC	TCGA	TRFTLTGLK	DEG_APCC_DBOX_1	0.3056
p.D970H	DO14286	HNSC	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	0.3056
p.T983I	TCGA-CV-7568	HNSC	TCGA	TRFTLTGLK	DEG_APCC_DBOX_1	0.2222
p.T983I	DO14160	HNSC	ICGC	TRFTLTGLK	DEG_APCC_DBOX_1	0.2222
p.Q965P	SIDM00683	Prostate Carcinoma	GDSC	TRFTLTGLK	DEG_APCC_DBOX_1	0.1667
p.D985H	SIDM00311	Mesothelioma	GDSC	TRFTLTGLK	DEG_APCC_DBOX_1	0.1667
p.D985H	H2810	pleura	COSMIC	TRFTLTGLK	DEG_APCC_DBOX_1	0.1667
p.D976H	H2810	pleura	COSMIC	TRFTLTGLK	DEG_APCC_DBOX_1	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10586	Receptor-type tyrosine-protein phosphatase F	DEG_APCC_DBOX_1	971:979	TRFTLTGLK	APC,CDC20,FZR1	0.837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons