DegronMD

Uniprot ID: P10586

Source protein: Receptor-type tyrosine-protein phosphatase F

Source gene: PTPRF

Class: DEG_SCF_FBW7_2

Location: 592:598

E3 ligase: FBXW7

DEGRON score: 0.9758

ASA_SCORE: 69.5714

COIL: 0.6017

CONS_SCORE: 0.4278

DSS_SCORE: 0.3937

HELIX: 0.0064

FCONS_SCORE: 0.8601

RIG_SCORE: 0.8055

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T594A	TCGA-D8-A1XK	BRCA	TCGA	VFTPTIE	DEG_SCF_FBW7_2	0.825
p.T594A	DO4749	BRCA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.825
p.T594S	ACH-001970	Metastasis	CCLE	VFTPTIE	DEG_SCF_FBW7_2	0.8227
p.P595A	TCGA-BQ-5876	KIRP	TCGA	VFTPTIE	DEG_SCF_FBW7_2	0.7503
p.P595A	DO20759	KIRP	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.7503
p.V592I	DO51082	PRAD	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.5965
p.V592I	SIDM00343	Glioblastoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	0.5965
p.V592I	SIDM00027	Kidney Carcinoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	0.5965
p.V592I	SIDM01101	Neuroblastoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	0.5965
p.V592I	SIDM00105	Ovarian Carcinoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	0.5965
p.V592I	SIDM00093	Ovarian Carcinoma	GDSC	VFTPTIE	DEG_SCF_FBW7_2	0.5965
p.R600S	TCGA-05-4396	LUAD	TCGA	VFTPTIE	DEG_SCF_FBW7_2	0.2778
p.R600S	DO23838	LUAD	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.2778
p.R600H	TCGA-EO-A22U	UCEC	TCGA	VFTPTIE	DEG_SCF_FBW7_2	0.2778
p.R600H	DO43755	UCEC	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.2778
p.A602S	DO229026	LICA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.2222
p.P606H	TCGA-AB-2821	LAML	TCGA	VFTPTIE	DEG_SCF_FBW7_2	0.1111
p.P606H	DO21655	LAML	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.1111
p.A584V	TCGA-CV-7245	HNSC	TCGA	VFTPTIE	DEG_SCF_FBW7_2	0.1111
p.A584V	DO14322	HNSC	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.1111
p.A584S	DO229026	LICA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.1111
p.S607P	DO229224	THCA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.0833
p.S607P	DO229234	THCA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.0833
p.A608P	DO229229	THCA	ICGC	VFTPTIE	DEG_SCF_FBW7_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10586	Receptor-type tyrosine-protein phosphatase F	DEG_SCF_FBW7_2	592:598	VFTPTIE	FBXW7	0.9758	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons