DegronMD

Uniprot ID: O94850

Source protein: Dendrin

Source gene: DDN

Class: DEG_SCF_FBW7_1

Location: 257:264

E3 ligase: FBXW7

DEGRON score: 0.9555

ASA_SCORE: 89.8625

COIL: 0.951

CONS_SCORE: 0.6811

DSS_SCORE: 0.7455

HELIX: 0.0224

FCONS_SCORE: 0.8348

RIG_SCORE: 0.6403

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A262V	TCGA-CD-A4MJ	STAD	TCGA	PAATPART	DEG_SCF_FBW7_1	0.5825
p.A262V	DO47811	STAD	ICGC	PAATPART	DEG_SCF_FBW7_1	0.5825
p.A262T	TCGA-CM-6170	COAD	TCGA	PAATPART	DEG_SCF_FBW7_1	0.6028
p.A262T	DO7849	COAD	ICGC	PAATPART	DEG_SCF_FBW7_1	0.6028
p.D265N	TCGA-CN-4723	HNSC	TCGA	PAATPART	DEG_SCF_FBW7_1	0.3056
p.D265N	DO14830	HNSC	ICGC	PAATPART	DEG_SCF_FBW7_1	0.3056
p.D265E	DO229041	LICA	ICGC	PAATPART	DEG_SCF_FBW7_1	0.3056
p.R272S	DO229509	PRAD	ICGC	PAATPART	DEG_SCF_FBW7_1	0.1111
p.R272S	SIDM01706	Hodgkin's Lymphoma	GDSC	PAATPART	DEG_SCF_FBW7_1	0.1111
p.R272S	ACH-001093	Non-Cancerous	CCLE	PAATPART	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94850	Dendrin	DEG_SCF_FBW7_1	257:264	PAATPART	FBXW7	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons