DegronMD

Uniprot ID: O75038

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Source gene: PLCH2

Class: DEG_SPOP_SBC_1

Location: 1022:1026

E3 ligase: SPOP

DEGRON score: 0.7337

ASA_SCORE: 83.12

COIL: 0.931

CONS_SCORE: 0.3323

DSS_SCORE: 0.7916

HELIX: 0.0144

FCONS_SCORE: 0.9838

RIG_SCORE: 0.5391

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1032Q	DO234389	ESAD	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.R1019K	DO11854	GBM	ICGC	VPTSS	DEG_SPOP_SBC_1	0.25
p.E1033K	DO229505	LAML	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1389
p.P1017L	SIDM00524	Small Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.P1017L	SIDM00535	Chondrosarcoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.P1017L	SIDM00889	Cervical Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.P1017L	SIDM00564	Ovarian Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.P1017L	SIDM00357	Small Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.P1017L	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.P1017L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.P1017L	SIDM00243	Other Solid Cancers	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.R1030W	SIDM00505	Pancreatic Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.2222
p.P1034T	ACH-001097	Lymphoma	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_SPOP_SBC_1	1022:1026	VPTSS	SPOP	0.7337	More...
O75604	Ubiquitin carboxyl-terminal hydrolase 2	DEG_SPOP_SBC_1	54:58	VPTSS	SPOP	0.9881	More...
O94850	Dendrin	DEG_SPOP_SBC_1	251:255	VPTSS	SPOP	0.9712	More...
P22307	Sterol carrier protein 2	DEG_SPOP_SBC_1	422:426	VPTSS	SPOP	0.6008	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	546:550	VPTSS	SPOP	0.9975	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2863:2867	VPTSS	SPOP	0.9646	More...
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	DEG_SPOP_SBC_1	41:45	VPTSS	SPOP	0.8246	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	331:335	VPTSS	SPOP	0.9924	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	471:475	VPTSS	SPOP	0.9372	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12511:12515	VPTSS	SPOP	0.96	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12667:12671	VPTSS	SPOP	0.9914	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1602:1606	VPTSS	SPOP	0.9498	More...
P60413	Keratin-associated protein 10-12	DEG_SPOP_SBC_1	216:220	VPTSS	SPOP	0.7395	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	927:931	VPTSS	SPOP	0.8818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons