DegronMD - Q01973(ROR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V41L	TCGA-13-1481	OV	TCGA	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.6765
p.V41L	DO31789	OV	ICGC	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.6765
p.P826L	TCGA-97-A4M0	LUAD	TCGA	PPGY	ITCH	825:828	Mutation altering degron motif	0.7582
p.P818S	TCGA-EE-A3AA	SKCM	TCGA	PPGY	ITCH	825:828	Mutation rewiring degron network	0.1389
p.P818S	DO222632	MELA	ICGC	PPGY	ITCH	825:828	Mutation rewiring degron network	0.1389
p.P818S	DO37571	SKCM	ICGC	PPGY	ITCH	825:828	Mutation rewiring degron network	0.1389
p.P826S	TCGA-FR-A726	SKCM	TCGA	PPGY	ITCH	825:828	Mutation altering degron motif	0.6752
p.P826S	DO48665	SKCM	ICGC	PPGY	ITCH	825:828	Mutation altering degron motif	0.6752
p.S330L	TCGA-HU-A4GH	STAD	TCGA	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.1111
p.S330L	DO47743	STAD	ICGC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.1111
p.V325I	TCGA-HU-A4GT	STAD	TCGA	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.25
p.V325I	DO48020	STAD	ICGC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.25
p.S49A	TCGA-IB-7651	PAAD	TCGA	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.S49A	DO46657	PAAD	ICGC	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.P825S	TCGA-W3-AA1V	SKCM	TCGA	PPGY	ITCH	825:828	Mutation altering degron motif	0.6752
p.P825S	DO51276	SKCM	ICGC	PPGY	ITCH	825:828	Mutation altering degron motif	0.6752
p.Q49K	DO223588	BLCA	ICGC	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.G827A	DO222736	BTCA	ICGC	PPGY	ITCH	825:828	Mutation altering degron motif	0.6429
p.G41R	DO10036	COAD	ICGC	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7568
p.G41R	DO28942	OV	ICGC	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7568
p.T328A	DO234259	ESAD	ICGC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.1667
p.T328A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.1667
p.T328A	ACH-002059	Leukemia	CCLE	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.1667
p.T328A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.1667
p.R332C	DO222630	ESCA	ICGC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.0556
p.R332C	ACH-001610	Brain Cancer	CCLE	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.0556
p.V325F	DO229019	LICA	ICGC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.25
p.G827E	DO23408	LINC	ICGC	PPGY	ITCH	825:828	Mutation altering degron motif	0.6087
p.G32W	DO26423	LUSC	ICGC	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0833
p.G41E	DO222908	MELA	ICGC	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7199
p.E55G	DO52402	UCEC	ICGC	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0556
p.G318C	SIDM00373	Endometrial Carcinoma	GDSC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.2778
p.G318C	ACH-000974	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.2778
p.A830S	SIDM00291	Melanoma	GDSC	PPGY	ITCH	825:828	Mutation rewiring degron network	0.2778
p.A830S	ACH-002040	Skin Cancer	CCLE	PPGY	ITCH	825:828	Mutation rewiring degron network	0.2778
p.A830S	HMV-II	skin	COSMIC	PPGY	ITCH	825:828	Mutation rewiring degron network	0.2778
p.G323E	SIDM01060	Melanoma	GDSC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.3056
p.G323E	ACH-000882	Skin Cancer	CCLE	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.3056
p.G323E	IGR-1	skin	COSMIC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.3056
p.A834S	SIDM00699	Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	825:828	Mutation rewiring degron network	0.1667
p.A834S	ACH-001138	Lung Cancer	CCLE	PPGY	ITCH	825:828	Mutation rewiring degron network	0.1667
p.A834S	NCI-H2141	lung	COSMIC	PPGY	ITCH	825:828	Mutation rewiring degron network	0.1667
p.A834T	SIDM01617	Endometrial Carcinoma	GDSC	PPGY	ITCH	825:828	Mutation rewiring degron network	0.1667
p.A834T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	825:828	Mutation rewiring degron network	0.1667
p.I824T	ACH-001664	Gastric Cancer	CCLE	PPGY	ITCH	825:828	Mutation rewiring degron network	0.3056
p.R48Q	NCI-H630	large intestine	COSMIC	VPTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.25
p.S815I	HCT-15	large intestine	COSMIC	PPGY	ITCH	825:828	Mutation rewiring degron network	0.0556
p.E315G	SK-GT-4	oesophagus	COSMIC	DYR	CBL_MET	320:322	Mutation rewiring degron network	0.1944

Kaplan plot for ROR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ROR1

UniProt ID: Q01973

Entrez ID: 4919

Protein name: Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ROR1 in