DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DYR
Uniprot ID:
Q01973
Source protein:
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Source gene:
ROR1
Class:
CBL_MET
Location:
320:322
E3 ligase:
CBL
DEGRON score:
0.9644
ASA_SCORE:
76.5333
COIL:
0.0947
CONS_SCORE:
0.6423
DSS_SCORE:
0.3084
HELIX:
0.003
FCONS_SCORE:
1.1899
RIG_SCORE:
0.7779
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G323E
SIDM01060
Melanoma
GDSC
DYR
CBL_MET
0.3056
p.G323E
ACH-000882
Skin Cancer
CCLE
DYR
CBL_MET
0.3056
p.G323E
IGR-1
skin
COSMIC
DYR
CBL_MET
0.3056
p.G318C
SIDM00373
Endometrial Carcinoma
GDSC
DYR
CBL_MET
0.2778
p.G318C
ACH-000974
Endometrial/Uterine Cancer
CCLE
DYR
CBL_MET
0.2778
p.V325I
TCGA-HU-A4GT
STAD
TCGA
DYR
CBL_MET
0.25
p.V325I
DO48020
STAD
ICGC
DYR
CBL_MET
0.25
p.V325F
DO229019
LICA
ICGC
DYR
CBL_MET
0.25
p.E315G
SK-GT-4
oesophagus
COSMIC
DYR
CBL_MET
0.1944
p.T328A
DO234259
ESAD
ICGC
DYR
CBL_MET
0.1667
p.T328A
SIDM00364
B-Lymphoblastic Leukemia
GDSC
DYR
CBL_MET
0.1667
p.T328A
ACH-002059
Leukemia
CCLE
DYR
CBL_MET
0.1667
p.T328A
P30-OHK
haematopoietic_and_lymphoid_tissue
COSMIC
DYR
CBL_MET
0.1667
p.S330L
TCGA-HU-A4GH
STAD
TCGA
DYR
CBL_MET
0.1111
p.S330L
DO47743
STAD
ICGC
DYR
CBL_MET
0.1111
p.R332C
DO222630
ESCA
ICGC
DYR
CBL_MET
0.0556
p.R332C
ACH-001610
Brain Cancer
CCLE
DYR
CBL_MET
0.0556
Showing 1 to 17 of 17 entries
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Drug responses associated with ROR1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of DYR
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y2I7
1-phosphatidylinositol 3-phosphate 5-kinase
CBL_MET
1154:1156
DYR
CBL
0.9899
More...
P62333
26S proteasome regulatory subunit 10B
CBL_MET
11:13
DYR
CBL
0.5589
More...
Q96A35
39S ribosomal protein L24, mitochondrial
CBL_MET
103:105
DYR
CBL
0.8186
More...
Q9P2N4
A disintegrin and metalloproteinase with thrombospondin motifs 9
CBL_MET
1313:1315
DYR
CBL
0.9337
More...
Q12802
A-kinase anchor protein 13
CBL_MET
823:825
DYR
CBL
0.8159
More...
Q96K21
Abscission/NoCut checkpoint regulator
CBL_MET
348:350
DYR
CBL
0.5257
More...
P40145
Adenylate cyclase type 8
CBL_MET
1148:1150
DYR
CBL
0.7268
More...
P51825
AF4/FMR2 family member 1
CBL_MET
316:318
DYR
CBL
0.9069
More...
Q9P0K7
Ankycorbin
CBL_MET
661:663
DYR
CBL
0.6245
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Q6UB99
Ankyrin repeat domain-containing protein 11
CBL_MET
864:866
DYR
CBL
0.5334
More...
Q6UB99
Ankyrin repeat domain-containing protein 11
CBL_MET
899:901
DYR
CBL
0.7809
More...
Q96NW4
Ankyrin repeat domain-containing protein 27
CBL_MET
666:668
DYR
CBL
0.9069
More...
Q8N944
APC membrane recruitment protein 3
CBL_MET
128:130
DYR
CBL
0.9544
More...
Q9BZC7
ATP-binding cassette sub-family A member 2
CBL_MET
1395:1397
DYR
CBL
0.9909
More...
Q08211
ATP-dependent RNA helicase A
CBL_MET
1233:1235
DYR
CBL
0.9757
More...
O00571
ATP-dependent RNA helicase DDX3X
CBL_MET
601:603
DYR
CBL
0.9982
More...
O15523
ATP-dependent RNA helicase DDX3Y
CBL_MET
599:601
DYR
CBL
0.9998
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
56:58
DYR
CBL
0.7315
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
60:62
DYR
CBL
0.9219
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
407:409
DYR
CBL
0.8675
More...
A2AJT9
BCLAF1 and THRAP3 family member 3
CBL_MET
280:282
DYR
CBL
0.8797
More...
Q9NWK9
Box C/D snoRNA protein 1
CBL_MET
277:279
DYR
CBL
0.8233
More...
Q9NSI6
Bromodomain and WD repeat-containing protein 1
CBL_MET
563:565
DYR
CBL
0.9622
More...
P25440
Bromodomain-containing protein 2
CBL_MET
407:409
DYR
CBL
0.9586
More...
Q2TAL6
Brorin
CBL_MET
149:151
DYR
CBL
0.987
More...
Showing 1 to 25 of 231 entries
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