DegronMD - O00139(KIF2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P595T	TCGA-CD-A4MI	STAD	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7031
p.P595T	SIDM00379	Glioma	GDSC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7031
p.P595T	SK-MG-1	central nervous system	COSMIC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7031
p.D580N	TCGA-D3-A51R	SKCM	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.D580N	DO47480	SKCM	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.D203Y	TCGA-EO-A3B0	UCEC	TCGA	DYR	CBL_MET	209:211	Mutation rewiring degron network	0.1667
p.V593A	TCGA-EO-A3B0	UCEC	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.6936
p.V593A	TCGA-EY-A1GI	UCEC	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.6936
p.R587M	TCGA-ER-A19P	SKCM	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.3056
p.R587M	DO47623	SKCM	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.3056
p.R602C	TCGA-FW-A3R5	SKCM	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1667
p.F581V	TCGA-Q1-A73O	CESC	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.F581V	DO51612	CESC	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.M602T	DO225353	BRCA	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1667
p.A598V	DO5521	BRCA	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.D206H	DO50340	ESAD	ICGC	DYR	CBL_MET	209:211	Mutation rewiring degron network	0.25
p.E601D	DO229027	LICA	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.V207F	DO229036	LICA	ICGC	DYR	CBL_MET	209:211	Mutation blocking phosphorylation signal	0.7222
p.V207F	DO229037	LICA	ICGC	DYR	CBL_MET	209:211	Mutation blocking phosphorylation signal	0.7222
p.W592L	DO229036	LICA	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7015
p.R591Q	DO45368	LUAD	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7329
p.M209I	DO37405	SKCM	ICGC	DYR	CBL_MET	209:211	Mutation altering degron motif	0.7618
p.E594K	DO50280	SKCM	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7022
p.P213Q	DO47636	SKCM	ICGC	DYR	CBL_MET	209:211	Mutation rewiring degron network	0.2778
p.P213S	DO51761	STAD	ICGC	DYR	CBL_MET	209:211	Mutation rewiring degron network	0.2778
p.K205T	DO219773	UCEC	ICGC	DYR	CBL_MET	209:211	Mutation rewiring degron network	0.2222
p.R591W	DO42713	UCEC	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8634
p.F581I	SIDM01040	Ovarian Carcinoma	GDSC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.F581I	FU-OV-1	ovary	COSMIC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.R602H	SIDM01608	Endometrial Carcinoma	GDSC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1667
p.C205Y	ACH-000999	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	209:211	Mutation rewiring degron network	0.2222
p.C205Y	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	209:211	Mutation rewiring degron network	0.2222
p.A598S	451Lu	skin	COSMIC	QRDDLKLLC	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.C205F	KYSE-270	oesophagus	COSMIC	DYR	CBL_MET	209:211	Mutation rewiring degron network	0.2222

Kaplan plot for KIF2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF2A

UniProt ID: O00139

Entrez ID: 3796

Protein name: Kinesin-like protein KIF2A (Kinesin-2) (hK2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF2A in