DegronMD

Uniprot ID: O00139

Source protein: Kinesin-like protein KIF2A

Source gene: KIF2A

Class: DEG_APCC_DBOX_1

Location: 588:596

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.998

ASA_SCORE: 84.5

COIL: 0.3807

CONS_SCORE: 0.4419

DSS_SCORE: 0.5634

HELIX: 0.5853

FCONS_SCORE: 1.2432

RIG_SCORE: 0.7809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P595T	TCGA-CD-A4MI	STAD	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	0.7031
p.P595T	SIDM00379	Glioma	GDSC	QRDDLKLLC	DEG_APCC_DBOX_1	0.7031
p.P595T	SK-MG-1	central_nervous_system	COSMIC	QRDDLKLLC	DEG_APCC_DBOX_1	0.7031
p.D580N	TCGA-D3-A51R	SKCM	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	0.1111
p.D580N	DO47480	SKCM	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.1111
p.V593A	TCGA-EO-A3B0	UCEC	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	0.6936
p.V593A	TCGA-EY-A1GI	UCEC	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	0.6936
p.R587M	TCGA-ER-A19P	SKCM	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	0.3056
p.R587M	DO47623	SKCM	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.3056
p.R602C	TCGA-FW-A3R5	SKCM	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	0.1667
p.F581V	TCGA-Q1-A73O	CESC	TCGA	QRDDLKLLC	DEG_APCC_DBOX_1	0.1389
p.F581V	DO51612	CESC	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.1389
p.M602T	DO225353	BRCA	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.1667
p.A598V	DO5521	BRCA	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.2778
p.E601D	DO229027	LICA	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.1944
p.W592L	DO229036	LICA	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.7015
p.R591Q	DO45368	LUAD	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.7329
p.E594K	DO50280	SKCM	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.7022
p.R591W	DO42713	UCEC	ICGC	QRDDLKLLC	DEG_APCC_DBOX_1	0.8634
p.F581I	SIDM01040	Ovarian Carcinoma	GDSC	QRDDLKLLC	DEG_APCC_DBOX_1	0.1389
p.F581I	FU-OV-1	ovary	COSMIC	QRDDLKLLC	DEG_APCC_DBOX_1	0.1389
p.R602H	SIDM01608	Endometrial Carcinoma	GDSC	QRDDLKLLC	DEG_APCC_DBOX_1	0.1667
p.A598S	451Lu	skin	COSMIC	QRDDLKLLC	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00139	Kinesin-like protein KIF2A	DEG_APCC_DBOX_1	588:596	QRDDLKLLC	APC,CDC20,FZR1	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons