DegronMD - Q96J84(KIRREL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V608M	SIDM02072	Colorectal Carcinoma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation rewiring degron network	0.0556
p.A631T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation rewiring degron network	0.1389
p.A631T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.1944
p.A631T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation rewiring degron network	0.1389
p.A631T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.1944
p.A627T	SIDM01020	Plasma Cell Myeloma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation rewiring degron network	0.25
p.A627T	SIDM01020	Plasma Cell Myeloma	GDSC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.3056
p.A627T	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation rewiring degron network	0.25
p.A627T	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.3056
p.R632H	SIDM01119	Other Solid Cancers	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation rewiring degron network	0.1111
p.R632H	SIDM01119	Other Solid Cancers	GDSC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.1667
p.R108C	SIDM00832	Colorectal Carcinoma	GDSC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.2778
p.R108C	SW948	large intestine	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.2778
p.T103A	SIDM01045	Endometrial Carcinoma	GDSC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1389
p.T103A	EN	endometrium	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1389
p.A623T	SIDM01088	Endometrial Carcinoma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation altering degron motif	0.6028
p.A623T	RL95-2	endometrium	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation altering degron motif	0.6028
p.R632C	SIDM00930	Osteosarcoma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation rewiring degron network	0.1111
p.R632C	SIDM00930	Osteosarcoma	GDSC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.1667
p.R632C	CAL-72	bone	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation rewiring degron network	0.1111
p.R632C	CAL-72	bone	COSMIC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.1667
p.R440C	SIDM00431	T-Lymphoblastic Leukemia	GDSC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1111
p.R440C	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1111
p.I125F	SIDM00668	Non-Cancerous	GDSC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1389
p.I125F	Hs-445	haematopoietic and lymphoid tissue	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1389
p.P665L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	NTYSRGP	CBL_PTK	651:657	Mutation rewiring degron network	0.1111
p.P665L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	NTYSRGP	CBL_PTK	651:657	Mutation rewiring degron network	0.1111
p.S654N	SIDM00150	Colorectal Carcinoma	GDSC	NTYSRGP	CBL_PTK	651:657	Mutation altering degron motif	0.818
p.S654N	KM12	large intestine	COSMIC	NTYSRGP	CBL_PTK	651:657	Mutation altering degron motif	0.818
p.G635D	SIDM00980	Gastric Carcinoma	GDSC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.0833
p.G635D	23132-87	stomach	COSMIC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.0833
p.V620M	SIDM00780	Colorectal Carcinoma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation altering degron motif	0.6097
p.V435M	SIDM01546	Kidney Carcinoma	GDSC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.25
p.A112G	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation altering degron motif	0.6429
p.V102I	CW-2	large intestine	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.1111
p.R618Q	PF-382	haematopoietic and lymphoid tissue	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation altering degron motif	0.7329
p.R618Q	BE-13	haematopoietic and lymphoid tissue	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	618:624	Mutation altering degron motif	0.7329
p.Y421H	SNG-M	endometrium	COSMIC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1389
p.A441T	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.0833
p.M434I	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2778
p.F636S	MZ7-mel	skin	COSMIC	DYR	CBL_MET	624:626	Mutation rewiring degron network	0.0556
p.L436M	REH	haematopoietic and lymphoid tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222
p.P122T	RKO	large intestine	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.2222
p.P112H	KYSE-450	oesophagus	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation altering degron motif	0.7694
p.A437T	RL95-2	endometrium	COSMIC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1944
p.R423H	PF-382	haematopoietic and lymphoid tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1944
p.P122H	SK-OV-3	ovary	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	110:118	Mutation rewiring degron network	0.2222
p.T442S	FU-OV-1	ovary	COSMIC	WKENF	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.0556

Kaplan plot for KIRREL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIRREL1

UniProt ID: Q96J84

Entrez ID: 55243

Protein name: Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIRREL1 in