DegronMD

Uniprot ID: Q96J84

Source protein: Kin of IRRE-like protein 1

Source gene: KIRREL1

Class: CBL_PTK

Location: 651:657

E3 ligase: CBL

DEGRON score: 0.9978

ASA_SCORE: 60.6857

COIL: 0.7483

CONS_SCORE: 0.3799

DSS_SCORE: 0.6298

HELIX: 0.0339

FCONS_SCORE: 1.265

RIG_SCORE: 0.6049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P665L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	NTYSRGP	CBL_PTK	0.1111
p.P665L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	NTYSRGP	CBL_PTK	0.1111
p.S654N	SIDM00150	Colorectal Carcinoma	GDSC	NTYSRGP	CBL_PTK	0.818
p.S654N	KM12	large_intestine	COSMIC	NTYSRGP	CBL_PTK	0.818

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J84	Kin of IRRE-like protein 1	CBL_PTK	651:657	NTYSRGP	CBL	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons