DegronMD

Uniprot ID: Q96J84

Source protein: Kin of IRRE-like protein 1

Source gene: KIRREL1

Class: DEG_APCC_KENBOX_2

Location: 428:432

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5351

ASA_SCORE: 85.74

COIL: 0.564

CONS_SCORE: 0.3987

DSS_SCORE: 0.2174

HELIX: 0.0506

FCONS_SCORE: 0.84

RIG_SCORE: 0.9265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R440C	SIDM00431	T-Lymphoblastic Leukemia	GDSC	WKENF	DEG_APCC_KENBOX_2	0.1111
p.R440C	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	0.1111
p.V435M	SIDM01546	Kidney Carcinoma	GDSC	WKENF	DEG_APCC_KENBOX_2	0.25
p.Y421H	SNG-M	endometrium	COSMIC	WKENF	DEG_APCC_KENBOX_2	0.1389
p.A441T	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	0.0833
p.M434I	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	0.2778
p.L436M	REH	haematopoietic_and_lymphoid_tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	0.2222
p.A437T	RL95-2	endometrium	COSMIC	WKENF	DEG_APCC_KENBOX_2	0.1944
p.R423H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	WKENF	DEG_APCC_KENBOX_2	0.1944
p.T442S	FU-OV-1	ovary	COSMIC	WKENF	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J84	Kin of IRRE-like protein 1	DEG_APCC_KENBOX_2	428:432	WKENF	APC,CDC20,FZR1	0.5351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons