DegronMD

Uniprot ID: Q96J84

Source protein: Kin of IRRE-like protein 1

Source gene: KIRREL1

Class: LIG_APCC_ABBAyCdc20_2

Location: 618:624

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9088

ASA_SCORE: 59.8857

COIL: 0.5444

CONS_SCORE: 0.3717

DSS_SCORE: 0.4858

HELIX: 0.0541

FCONS_SCORE: 1.0803

RIG_SCORE: 0.7804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V608M	SIDM02072	Colorectal Carcinoma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A631T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A631T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A627T	SIDM01020	Plasma Cell Myeloma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.25
p.A627T	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.25
p.R632H	SIDM01119	Other Solid Cancers	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A623T	SIDM01088	Endometrial Carcinoma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.6028
p.A623T	RL95-2	endometrium	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.6028
p.R632C	SIDM00930	Osteosarcoma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R632C	CAL-72	bone	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.1111
p.V620M	SIDM00780	Colorectal Carcinoma	GDSC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.6097
p.R618Q	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R618Q	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLYAD	LIG_APCC_ABBAyCdc20_2	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J84	Kin of IRRE-like protein 1	LIG_APCC_ABBAyCdc20_2	618:624	RAVLYAD	APC,CDC20,FZR1	0.9088	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons