DegronMD

Uniprot ID: Q96J84

Source protein: Kin of IRRE-like protein 1

Source gene: KIRREL1

Class: DEG_APCC_DBOX_1

Location: 110:118

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9548

ASA_SCORE: 51.6

COIL: 0.1416

CONS_SCORE: 0.6351

DSS_SCORE: 0.3363

HELIX: 0.0031

FCONS_SCORE: 1.205

RIG_SCORE: 0.7957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R108C	SIDM00832	Colorectal Carcinoma	GDSC	RRAKLTVLI	DEG_APCC_DBOX_1	0.2778
p.R108C	SW948	large_intestine	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	0.2778
p.T103A	SIDM01045	Endometrial Carcinoma	GDSC	RRAKLTVLI	DEG_APCC_DBOX_1	0.1389
p.T103A	EN	endometrium	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	0.1389
p.I125F	SIDM00668	Non-Cancerous	GDSC	RRAKLTVLI	DEG_APCC_DBOX_1	0.1389
p.I125F	Hs-445	haematopoietic_and_lymphoid_tissue	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	0.1389
p.A112G	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	0.6429
p.V102I	CW-2	large_intestine	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	0.1111
p.P122T	RKO	large_intestine	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	0.2222
p.P112H	KYSE-450	oesophagus	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	0.7694
p.P122H	SK-OV-3	ovary	COSMIC	RRAKLTVLI	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J84	Kin of IRRE-like protein 1	DEG_APCC_DBOX_1	110:118	RRAKLTVLI	APC,CDC20,FZR1	0.9548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons