DegronMD - Q9P0K7(RAI14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E677K	TCGA-18-3417	LUSC	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1944
p.S670Y	TCGA-AX-A2HC	UCEC	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.712
p.S670Y	TCGA-CA-6717	COAD	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.712
p.Y678H	TCGA-BR-8487	STAD	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation substituting flanking lysine	0.2778
p.K669Q	TCGA-BT-A20N	BLCA	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.6944
p.S675F	DO44978	LIHC	ICGC	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation blocking phosphorylation signal	0.6944
p.A669V	DO222880	MELA	ICGC	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.6936
p.H652R	DO33004	PACA	ICGC	DYR	CBL_MET	661:663	Mutation rewiring degron network	0.0833
p.Q676K	DO47469	SKCM	ICGC	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.2222
p.L658V	DO42312	UCEC	ICGC	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1667
p.L658V	DO42312	UCEC	ICGC	DYR	CBL_MET	661:663	Mutation rewiring degron network	0.25
p.R663M	DO42665	UCEC	ICGC	DYR	CBL_MET	661:663	Mutation altering degron motif	0.8632
p.K656Q	SIDM00845	Burkitt's Lymphoma	GDSC	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1111
p.K656Q	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	661:663	Mutation rewiring degron network	0.1944
p.K656R	SIDM00845	Burkitt's Lymphoma	GDSC	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1111
p.K656R	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	661:663	Mutation rewiring degron network	0.1944
p.N682S	GP5d	large intestine	COSMIC	KRKSLEDVT	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.0556

Kaplan plot for RAI14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAI14

UniProt ID: Q9P0K7

Entrez ID: 26064

Protein name: Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAI14 in