DegronMD

Uniprot ID: Q9P0K7

Source protein: Ankycorbin

Source gene: RAI14

Class: DEG_APCC_DBOX_1

Location: 664:672

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7418

ASA_SCORE: 108.1778

COIL: 0.423

CONS_SCORE: 0.4731

DSS_SCORE: 0.3017

HELIX: 0.5709

FCONS_SCORE: 1.0325

RIG_SCORE: 0.7583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E677K	TCGA-18-3417	LUSC	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	0.1944
p.S670Y	TCGA-AX-A2HC	UCEC	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	0.712
p.S670Y	TCGA-CA-6717	COAD	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	0.712
p.Y678H	TCGA-BR-8487	STAD	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	0.2778
p.K669Q	TCGA-BT-A20N	BLCA	TCGA	KRKSLEDVT	DEG_APCC_DBOX_1	0.6944
p.S675F	DO44978	LIHC	ICGC	KRKSLEDVT	DEG_APCC_DBOX_1	0.6944
p.A669V	DO222880	MELA	ICGC	KRKSLEDVT	DEG_APCC_DBOX_1	0.6936
p.Q676K	DO47469	SKCM	ICGC	KRKSLEDVT	DEG_APCC_DBOX_1	0.2222
p.L658V	DO42312	UCEC	ICGC	KRKSLEDVT	DEG_APCC_DBOX_1	0.1667
p.K656Q	SIDM00845	Burkitt's Lymphoma	GDSC	KRKSLEDVT	DEG_APCC_DBOX_1	0.1111
p.K656R	SIDM00845	Burkitt's Lymphoma	GDSC	KRKSLEDVT	DEG_APCC_DBOX_1	0.1111
p.N682S	GP5d	large_intestine	COSMIC	KRKSLEDVT	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0K7	Ankycorbin	DEG_APCC_DBOX_1	664:672	KRKSLEDVT	APC,CDC20,FZR1	0.7418	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons