DegronMD - Q5VV43(KIAA0319)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G149D	TCGA-06-5416	GBM	TCGA	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.0556
p.G149D	DO10880	GBM	ICGC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.0556
p.P318T	TCGA-43-A56U	LUSC	TCGA	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.1111
p.P318T	DO49083	LUSC	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.1111
p.P237R	TCGA-44-2656	LUAD	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6401
p.P237R	DO26052	LUAD	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6401
p.E320K	TCGA-5L-AAT1	BRCA	TCGA	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.0556
p.E320K	DO219594	BRCA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.0556
p.P230H	TCGA-66-2742	LUSC	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P230H	DO26439	LUSC	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.E152Q	TCGA-85-8287	LUSC	TCGA	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1389
p.E152Q	DO27492	LUSC	ICGC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1389
p.P230T	TCGA-A5-A1OF	UCEC	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P230T	DO42568	UCEC	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.T286N	TCGA-AA-3875	COAD	TCGA	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.T286N	DO9282	COAD	ICGC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.S223T	TCGA-AB-2854	LAML	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1111
p.S223T	DO21625	LAML	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1111
p.D166N	TCGA-AB-2854	LAML	TCGA	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1944
p.D166N	DO21625	LAML	ICGC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1944
p.S314P	TCGA-AJ-A3EK	UCEC	TCGA	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.2222
p.S314P	DO41584	UCEC	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.2222
p.S299I	TCGA-AP-A0LM	UCEC	TCGA	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.623
p.S299I	DO43306	UCEC	ICGC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.623
p.E301D	TCGA-AX-A06F	UCEC	TCGA	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.3056
p.E301D	TCGA-AX-A06F	UCEC	TCGA	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.25
p.E301D	DO41752	UCEC	ICGC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.3056
p.E301D	DO41752	UCEC	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.25
p.E152D	TCGA-B6-A0IJ	BRCA	TCGA	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1389
p.E152D	DO2813	BRCA	ICGC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1389
p.E246Q	TCGA-CV-6942	HNSC	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1389
p.E246Q	DO15951	HNSC	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1389
p.A226T	TCGA-CW-5581	KIRC	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1944
p.A226T	TCGA-TQ-A8XE	LGG	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1944
p.A226T	DO19793	KIRC	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1944
p.A226T	DO223700	LGG	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1944
p.L150P	TCGA-DA-A3F3	SKCM	TCGA	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.0833
p.L150P	DO37607	SKCM	ICGC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.0833
p.R720S	TCGA-DD-AAD1	LIHC	TCGA	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.2222
p.R720S	DO52218	LIHC	ICGC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.2222
p.P230S	TCGA-EE-A2MD	SKCM	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P230S	TCGA-EE-A2ML	SKCM	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P230S	TCGA-W3-AA1W	SKCM	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P230S	DO222429	MELA	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P230S	DO222434	MELA	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P230S	DO37851	SKCM	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P230S	DO37408	SKCM	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P230S	DO51277	SKCM	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P718S	TCGA-EE-A3JA	SKCM	TCGA	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.2778
p.P718S	DO47625	SKCM	ICGC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.2778
p.E714D	TCGA-EI-6882	READ	TCGA	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation altering degron motif	0.6758
p.E714D	DO36531	READ	ICGC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation altering degron motif	0.6758
p.A312P	TCGA-G4-6320	COAD	TCGA	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.2778
p.A312P	DO8159	COAD	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.2778
p.T300R	TCGA-KU-A66S	HNSC	TCGA	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7876
p.T300R	DO44456	HNSC	ICGC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7876
p.P237S	TCGA-RW-A68F	PCPG	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.5641
p.T241I	TCGA-VQ-A8P2	STAD	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2778
p.T241I	DO51761	STAD	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2778
p.S283G	TCGA-VR-A8Q7	ESCA	TCGA	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.P305S	DO52643	BOCA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.5641
p.P305S	SIDM01175	Other Sarcomas	GDSC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.5641
p.P305S	ACH-002309	Sarcoma	CCLE	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.5641
p.P305S	SW684	soft tissue	COSMIC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.5641
p.A311T	DO229010	COCA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.A311T	DO229480	LAML	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.A311T	DO230659	LAML	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.A311T	DO231140	LAML	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.A311T	DO229047	LICA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.A311T	DO230990	LUSC	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.P239L	DO234329	ESAD	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6471
p.D158N	DO223068	ESCA	ICGC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.3056
p.A311E	DO228948	LICA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.3056
p.P291T	DO228974	LICA	ICGC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.A721D	DO228976	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.1944
p.P307H	DO229019	LICA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7694
p.S702R	DO229022	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.0556
p.T317N	DO229025	LICA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.1389
p.A710D	DO229031	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.2778
p.S702G	DO229058	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.0556
p.P170T	DO229009	LICA	ICGC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.0833
p.T309A	DO52663	MALY	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.6028
p.T224I	DO220851	MELA	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1389
p.S299R	DO220903	MELA	ICGC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6316
p.P230L	DO222638	MELA	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.P318L	DO222644	MELA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation rewiring degron network	0.1111
p.S154A	DO36556	READ	ICGC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1944
p.V711M	DO229240	THCA	ICGC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.3056
p.T306A	SIDM00578	Neuroblastoma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7139
p.T306A	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7139
p.T306A	SIDM00574	Glioblastoma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7139
p.T306A	SIDM01575	Plasma Cell Myeloma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7139
p.P307T	SIDM00373	Endometrial Carcinoma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7031
p.P307T	ACH-000974	Endometrial/Uterine Cancer	CCLE	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7031
p.P307T	ACH-002026	Endometrial/Uterine Cancer	CCLE	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7031
p.P307T	SNG-M	endometrium	COSMIC	IPTPPTS	DEG_SCF_FBW7_1	304:310	Mutation altering degron motif	0.7031
p.P297S	SIDM00545	Melanoma	GDSC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.P297S	ACH-000987	Skin Cancer	CCLE	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.P297S	Mewo	skin	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.S244L	SIDM00627	Cervical Carcinoma	GDSC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1944
p.S244L	ACH-001359	Cervical Cancer	CCLE	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1944
p.S244L	ME-180	cervix	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1944
p.V287M	SIDM00660	Colorectal Carcinoma	GDSC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1667
p.V287M	LS-411N	large intestine	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1667
p.S703N	SIDM01100	Neuroblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.0833
p.S703N	SIDM00049	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.0833
p.E155K	SIDM00151	Ovarian Carcinoma	GDSC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.2222
p.E155K	ACH-000966	Ovarian Cancer	CCLE	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.2222
p.E155K	IGROV-1	ovary	COSMIC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.2222
p.V292L	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.3056
p.V292L	ACH-000980	Lung Cancer	CCLE	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.3056
p.V292L	NCI-H1155	lung	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.3056
p.R232K	SIDM00462	Acute Myeloid Leukemia	GDSC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.7237
p.R232K	ACH-000336	Leukemia	CCLE	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.7237
p.R232K	OCI-AML3	haematopoietic and lymphoid tissue	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.7237
p.L231V	HT	haematopoietic and lymphoid tissue	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6765
p.L231V	H290	pleura	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6765
p.R223K	OCI-AML3	haematopoietic and lymphoid tissue	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1111
p.K288E	T47D	breast	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.S235L	ME-180	cervix	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.7667
p.P288S	Mewo	skin	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.V283L	NCI-H1155	lung	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.R167L	NCI-H1299	lung	COSMIC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1667
p.R298G	AMO-1	haematopoietic and lymphoid tissue	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7568
p.T164M	DMS-114	lung	COSMIC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.25
p.D167Y	NB14	autonomic ganglia	COSMIC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1667
p.R711L	NCI-H1299	lung	COSMIC	KKENN	DEG_APCC_KENBOX_2	712:716	Mutation rewiring degron network	0.3056
p.Q166K	LAN-6	autonomic ganglia	COSMIC	DYR	CBL_MET	159:161	Mutation rewiring degron network	0.1944
p.V242M	LS-411N	large intestine	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.25
p.G236V	NCI-H1792	lung	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.7532
p.P296S	SW684	soft tissue	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.V247L	NCI-H1155	lung	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1111
p.A159V	HCC70	breast	COSMIC	DYR	CBL_MET	159:161	Mutation altering degron motif	0.6936
p.P298T	SNG-M	endometrium	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA0319

UniProt ID: Q5VV43

Entrez ID: 9856

Protein name: Dyslexia-associated protein KIAA0319

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA0319 in