DegronMD

Uniprot ID: Q5VV43

Source protein: Dyslexia-associated protein KIAA0319

Source gene: KIAA0319

Class: DEG_SCF_FBW7_1

Location: 304:310

E3 ligase: FBXW7

DEGRON score: 0.6685

ASA_SCORE: 45.2429

COIL: 0.5814

CONS_SCORE: 0.3099

DSS_SCORE: 0.7585

HELIX: 0.0097

FCONS_SCORE: 1.1761

RIG_SCORE: 0.5883

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P318T	TCGA-43-A56U	LUSC	TCGA	IPTPPTS	DEG_SCF_FBW7_1	0.1111
p.P318T	DO49083	LUSC	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.1111
p.E320K	TCGA-5L-AAT1	BRCA	TCGA	IPTPPTS	DEG_SCF_FBW7_1	0.0556
p.E320K	DO219594	BRCA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.0556
p.S314P	TCGA-AJ-A3EK	UCEC	TCGA	IPTPPTS	DEG_SCF_FBW7_1	0.2222
p.S314P	DO41584	UCEC	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.2222
p.E301D	TCGA-AX-A06F	UCEC	TCGA	IPTPPTS	DEG_SCF_FBW7_1	0.25
p.E301D	DO41752	UCEC	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.25
p.A312P	TCGA-G4-6320	COAD	TCGA	IPTPPTS	DEG_SCF_FBW7_1	0.2778
p.A312P	DO8159	COAD	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.2778
p.P305S	DO52643	BOCA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.5641
p.P305S	SIDM01175	Other Sarcomas	GDSC	IPTPPTS	DEG_SCF_FBW7_1	0.5641
p.P305S	ACH-002309	Sarcoma	CCLE	IPTPPTS	DEG_SCF_FBW7_1	0.5641
p.P305S	SW684	soft_tissue	COSMIC	IPTPPTS	DEG_SCF_FBW7_1	0.5641
p.A311T	DO229010	COCA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.3056
p.A311T	DO229480	LAML	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.3056
p.A311T	DO230659	LAML	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.3056
p.A311T	DO231140	LAML	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.3056
p.A311T	DO229047	LICA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.3056
p.A311T	DO230990	LUSC	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.3056
p.A311E	DO228948	LICA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.3056
p.P307H	DO229019	LICA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.7694
p.T317N	DO229025	LICA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.1389
p.T309A	DO52663	MALY	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.6028
p.P318L	DO222644	MELA	ICGC	IPTPPTS	DEG_SCF_FBW7_1	0.1111
p.T306A	SIDM00578	Neuroblastoma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	0.7139
p.T306A	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	0.7139
p.T306A	SIDM00574	Glioblastoma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	0.7139
p.T306A	SIDM01575	Plasma Cell Myeloma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	0.7139
p.P307T	SIDM00373	Endometrial Carcinoma	GDSC	IPTPPTS	DEG_SCF_FBW7_1	0.7031
p.P307T	ACH-000974	Endometrial/Uterine Cancer	CCLE	IPTPPTS	DEG_SCF_FBW7_1	0.7031
p.P307T	ACH-002026	Endometrial/Uterine Cancer	CCLE	IPTPPTS	DEG_SCF_FBW7_1	0.7031
p.P307T	SNG-M	endometrium	COSMIC	IPTPPTS	DEG_SCF_FBW7_1	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPTPPTS

Degron related mutations and impact score

Drug responses associated with KIAA0319 mutations

All proteins holding degron of IPTPPTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_SCF_FBW7_1	304:310	IPTPPTS	FBXW7	0.6685	More...