DegronMD

Uniprot ID: Q5VV43

Source protein: Dyslexia-associated protein KIAA0319

Source gene: KIAA0319

Class: DEG_APCC_DBOX_1

Location: 231:239

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8465

ASA_SCORE: 77.1556

COIL: 0.6802

CONS_SCORE: 0.2779

DSS_SCORE: 0.6218

HELIX: 0.0151

FCONS_SCORE: 0.962

RIG_SCORE: 0.6842

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P237R	TCGA-44-2656	LUAD	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.6401
p.P237R	DO26052	LUAD	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.6401
p.P230H	TCGA-66-2742	LUSC	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230H	DO26439	LUSC	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230T	TCGA-A5-A1OF	UCEC	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230T	DO42568	UCEC	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.S223T	TCGA-AB-2854	LAML	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.1111
p.S223T	DO21625	LAML	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.1111
p.E246Q	TCGA-CV-6942	HNSC	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.1389
p.E246Q	DO15951	HNSC	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.1389
p.A226T	TCGA-CW-5581	KIRC	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.1944
p.A226T	TCGA-TQ-A8XE	LGG	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.1944
p.A226T	DO19793	KIRC	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.1944
p.A226T	DO223700	LGG	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.1944
p.P230S	TCGA-EE-A2MD	SKCM	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230S	TCGA-EE-A2ML	SKCM	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230S	TCGA-W3-AA1W	SKCM	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230S	DO222429	MELA	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230S	DO222434	MELA	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230S	DO37851	SKCM	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230S	DO37408	SKCM	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P230S	DO51277	SKCM	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.P237S	TCGA-RW-A68F	PCPG	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.5641
p.T241I	TCGA-VQ-A8P2	STAD	TCGA	ERSVLLPLP	DEG_APCC_DBOX_1	0.2778
p.T241I	DO51761	STAD	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.2778
p.P239L	DO234329	ESAD	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.6471
p.T224I	DO220851	MELA	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.1389
p.P230L	DO222638	MELA	ICGC	ERSVLLPLP	DEG_APCC_DBOX_1	0.3056
p.S244L	SIDM00627	Cervical Carcinoma	GDSC	ERSVLLPLP	DEG_APCC_DBOX_1	0.1944
p.S244L	ACH-001359	Cervical Cancer	CCLE	ERSVLLPLP	DEG_APCC_DBOX_1	0.1944
p.S244L	ME-180	cervix	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	0.1944
p.R232K	SIDM00462	Acute Myeloid Leukemia	GDSC	ERSVLLPLP	DEG_APCC_DBOX_1	0.7237
p.R232K	ACH-000336	Leukemia	CCLE	ERSVLLPLP	DEG_APCC_DBOX_1	0.7237
p.R232K	OCI-AML3	haematopoietic_and_lymphoid_tissue	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	0.7237
p.L231V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	0.6765
p.L231V	H290	pleura	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	0.6765
p.R223K	OCI-AML3	haematopoietic_and_lymphoid_tissue	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	0.1111
p.S235L	ME-180	cervix	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	0.7667
p.V242M	LS-411N	large_intestine	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	0.25
p.G236V	NCI-H1792	lung	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	0.7532
p.V247L	NCI-H1155	lung	COSMIC	ERSVLLPLP	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERSVLLPLP

Degron related mutations and impact score

Drug responses associated with KIAA0319 mutations

All proteins holding degron of ERSVLLPLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_APCC_DBOX_1	231:239	ERSVLLPLP	APC,CDC20,FZR1	0.8465	More...