DegronMD

Uniprot ID: Q5VV43

Source protein: Dyslexia-associated protein KIAA0319

Source gene: KIAA0319

Class: DEG_SCF_FBW7_1

Location: 293:300

E3 ligase: FBXW7

DEGRON score: 0.6936

ASA_SCORE: 45.5125

COIL: 0.4054

CONS_SCORE: 0.2585

DSS_SCORE: 0.6284

HELIX: 0.008

FCONS_SCORE: 0.8685

RIG_SCORE: 0.6248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T286N	TCGA-AA-3875	COAD	TCGA	LTVTPGST	DEG_SCF_FBW7_1	0.1389
p.T286N	DO9282	COAD	ICGC	LTVTPGST	DEG_SCF_FBW7_1	0.1389
p.S299I	TCGA-AP-A0LM	UCEC	TCGA	LTVTPGST	DEG_SCF_FBW7_1	0.623
p.S299I	DO43306	UCEC	ICGC	LTVTPGST	DEG_SCF_FBW7_1	0.623
p.E301D	TCGA-AX-A06F	UCEC	TCGA	LTVTPGST	DEG_SCF_FBW7_1	0.3056
p.E301D	DO41752	UCEC	ICGC	LTVTPGST	DEG_SCF_FBW7_1	0.3056
p.T300R	TCGA-KU-A66S	HNSC	TCGA	LTVTPGST	DEG_SCF_FBW7_1	0.7876
p.T300R	DO44456	HNSC	ICGC	LTVTPGST	DEG_SCF_FBW7_1	0.7876
p.S283G	TCGA-VR-A8Q7	ESCA	TCGA	LTVTPGST	DEG_SCF_FBW7_1	0.0556
p.P291T	DO228974	LICA	ICGC	LTVTPGST	DEG_SCF_FBW7_1	0.2778
p.S299R	DO220903	MELA	ICGC	LTVTPGST	DEG_SCF_FBW7_1	0.6316
p.P297S	SIDM00545	Melanoma	GDSC	LTVTPGST	DEG_SCF_FBW7_1	0.6752
p.P297S	ACH-000987	Skin Cancer	CCLE	LTVTPGST	DEG_SCF_FBW7_1	0.6752
p.P297S	Mewo	skin	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	0.6752
p.V287M	SIDM00660	Colorectal Carcinoma	GDSC	LTVTPGST	DEG_SCF_FBW7_1	0.1667
p.V287M	LS-411N	large_intestine	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	0.1667
p.V292L	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LTVTPGST	DEG_SCF_FBW7_1	0.3056
p.V292L	ACH-000980	Lung Cancer	CCLE	LTVTPGST	DEG_SCF_FBW7_1	0.3056
p.V292L	NCI-H1155	lung	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	0.3056
p.K288E	T47D	breast	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	0.1944
p.P288S	Mewo	skin	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	0.1944
p.V283L	NCI-H1155	lung	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	0.0556
p.R298G	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	0.7568
p.P296S	SW684	soft_tissue	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	0.6752
p.P298T	SNG-M	endometrium	COSMIC	LTVTPGST	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_SCF_FBW7_1	293:300	LTVTPGST	FBXW7	0.6936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons