DegronMD - Q99795(GPA33)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P171H	TCGA-17-Z028	LUAD	TCGA	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation altering degron motif	0.7694
p.G310E	TCGA-19-0957	GBM	TCGA	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1111
p.G310E	DO11028	GBM	ICGC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1111
p.G310E	DO220866	MELA	ICGC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1111
p.R295W	TCGA-39-5040	LUSC	TCGA	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1944
p.R295W	DO45436	LUSC	ICGC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1944
p.E294D	TCGA-39-5040	LUSC	TCGA	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1667
p.E294D	DO45436	LUSC	ICGC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1667
p.R302M	TCGA-44-8117	LUAD	TCGA	DYR	CBL_MET	300:302	Mutation altering degron motif	0.8632
p.R302M	DO24028	LUAD	ICGC	DYR	CBL_MET	300:302	Mutation altering degron motif	0.8632
p.W175L	TCGA-61-1730	OV	TCGA	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.3056
p.W175L	DO31859	OV	ICGC	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.3056
p.S168L	TCGA-63-7020	LUSC	TCGA	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.3056
p.S168L	DO27596	LUSC	ICGC	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.3056
p.R134H	TCGA-AA-A01P	COAD	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation altering degron motif	0.7133
p.R134H	TCGA-BS-A0UF	UCEC	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation altering degron motif	0.7133
p.R134H	DO8642	COAD	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation altering degron motif	0.7133
p.R134H	DO41488	UCEC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation altering degron motif	0.7133
p.P144Q	TCGA-CN-A497	HNSC	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1944
p.P144Q	DO218992	HNSC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1944
p.P144Q	DO229022	LICA	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1944
p.L136F	TCGA-DD-A3A9	LIHC	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation altering degron motif	0.587
p.L136F	DO44888	LIHC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation altering degron motif	0.587
p.S308I	TCGA-EO-A22X	UCEC	TCGA	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1667
p.S308I	DO43907	UCEC	ICGC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1667
p.G147D	TCGA-FI-A2F4	UCEC	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1111
p.G147D	DO43434	UCEC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1111
p.E166K	TCGA-FW-A3R5	SKCM	TCGA	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.25
p.E166K	DO220886	MELA	ICGC	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.25
p.E166K	DO37406	SKCM	ICGC	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.25
p.P171S	TCGA-GN-A266	SKCM	TCGA	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation altering degron motif	0.6752
p.P171S	DO37432	SKCM	ICGC	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation altering degron motif	0.6752
p.R307M	TCGA-IB-7651	PAAD	TCGA	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1944
p.R307M	DO46657	PAAD	ICGC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.1944
p.D299G	DO222913	BTCA	ICGC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.3056
p.T170N	DO229028	LICA	ICGC	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation altering degron motif	0.7055
p.E145Q	DO230961	LUSC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1667
p.T129I	DO222843	MELA	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.2778
p.E296K	DO229446	SKCA	ICGC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.2222
p.E126D	DO229259	THCA	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1944
p.P144A	SIDM00194	Colorectal Carcinoma	GDSC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1944
p.P144A	SIDM00437	Acute Myeloid Leukemia	GDSC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1944
p.P144A	SIDM00054	Pancreatic Carcinoma	GDSC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1944
p.R311P	SIDM00930	Osteosarcoma	GDSC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.0833
p.R311P	ACH-001715	Bone Cancer	CCLE	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.0833
p.R311P	CAL-72	bone	COSMIC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.0833
p.T161N	SIDM00863	Burkitt's Lymphoma	GDSC	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.1111
p.R311C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.0833
p.R311C	ACH-001127	Leukemia	CCLE	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.0833
p.R311C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	300:302	Mutation rewiring degron network	0.0833
p.K176R	SIDM00850	Gastric Carcinoma	GDSC	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.2778
p.K176R	ACH-000880	Gastric Cancer	CCLE	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.2778
p.K176R	AGS	stomach	COSMIC	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.2778
p.R134C	SIDM01664	Prostate Carcinoma	GDSC	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation altering degron motif	0.719
p.R134C	ACH-000952	Prostate Cancer	CCLE	SRVRLLVLV	DEG_APCC_DBOX_1	131:139	Mutation altering degron motif	0.719
p.E184D	ACH-000450	Skin Cancer	CCLE	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.0556
p.T161P	ACH-000722	Colon/Colorectal Cancer	CCLE	PTPQYS	DEG_SCF_FBW7_1	169:174	Mutation rewiring degron network	0.1111
p.D300E	ACH-001132	Lymphoma	CCLE	DYR	CBL_MET	300:302	Mutation altering degron motif	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPA33

UniProt ID: Q99795

Entrez ID: 10223

Protein name: Cell surface A33 antigen (Glycoprotein A33)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPA33 in