DegronMD

Uniprot ID: Q99795

Source protein: Cell surface A33 antigen

Source gene: GPA33

Class: DEG_SCF_FBW7_1

Location: 169:174

E3 ligase: FBXW7

DEGRON score: 0.6815

ASA_SCORE: 51.5

COIL: 0.4367

CONS_SCORE: 0.7578

DSS_SCORE: 0.4693

HELIX: 0.0082

FCONS_SCORE: 1.198

RIG_SCORE: 0.7133

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P171H	TCGA-17-Z028	LUAD	TCGA	PTPQYS	DEG_SCF_FBW7_1	0.7694
p.W175L	TCGA-61-1730	OV	TCGA	PTPQYS	DEG_SCF_FBW7_1	0.3056
p.W175L	DO31859	OV	ICGC	PTPQYS	DEG_SCF_FBW7_1	0.3056
p.S168L	TCGA-63-7020	LUSC	TCGA	PTPQYS	DEG_SCF_FBW7_1	0.3056
p.S168L	DO27596	LUSC	ICGC	PTPQYS	DEG_SCF_FBW7_1	0.3056
p.E166K	TCGA-FW-A3R5	SKCM	TCGA	PTPQYS	DEG_SCF_FBW7_1	0.25
p.E166K	DO220886	MELA	ICGC	PTPQYS	DEG_SCF_FBW7_1	0.25
p.E166K	DO37406	SKCM	ICGC	PTPQYS	DEG_SCF_FBW7_1	0.25
p.P171S	TCGA-GN-A266	SKCM	TCGA	PTPQYS	DEG_SCF_FBW7_1	0.6752
p.P171S	DO37432	SKCM	ICGC	PTPQYS	DEG_SCF_FBW7_1	0.6752
p.T170N	DO229028	LICA	ICGC	PTPQYS	DEG_SCF_FBW7_1	0.7055
p.T161N	SIDM00863	Burkitt's Lymphoma	GDSC	PTPQYS	DEG_SCF_FBW7_1	0.1111
p.K176R	SIDM00850	Gastric Carcinoma	GDSC	PTPQYS	DEG_SCF_FBW7_1	0.2778
p.K176R	ACH-000880	Gastric Cancer	CCLE	PTPQYS	DEG_SCF_FBW7_1	0.2778
p.K176R	AGS	stomach	COSMIC	PTPQYS	DEG_SCF_FBW7_1	0.2778
p.E184D	ACH-000450	Skin Cancer	CCLE	PTPQYS	DEG_SCF_FBW7_1	0.0556
p.T161P	ACH-000722	Colon/Colorectal Cancer	CCLE	PTPQYS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99795	Cell surface A33 antigen	DEG_SCF_FBW7_1	169:174	PTPQYS	FBXW7	0.6815	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons