DegronMD

Uniprot ID: Q99795

Source protein: Cell surface A33 antigen

Source gene: GPA33

Class: DEG_APCC_DBOX_1

Location: 131:139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6005

ASA_SCORE: 58.4333

COIL: 0.275

CONS_SCORE: 0.6396

DSS_SCORE: 0.3362

HELIX: 0.0074

FCONS_SCORE: 1.0722

RIG_SCORE: 0.8521

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R134H	TCGA-AA-A01P	COAD	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	0.7133
p.R134H	TCGA-BS-A0UF	UCEC	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	0.7133
p.R134H	DO8642	COAD	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	0.7133
p.R134H	DO41488	UCEC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	0.7133
p.P144Q	TCGA-CN-A497	HNSC	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	0.1944
p.P144Q	DO218992	HNSC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	0.1944
p.P144Q	DO229022	LICA	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	0.1944
p.L136F	TCGA-DD-A3A9	LIHC	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	0.587
p.L136F	DO44888	LIHC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	0.587
p.G147D	TCGA-FI-A2F4	UCEC	TCGA	SRVRLLVLV	DEG_APCC_DBOX_1	0.1111
p.G147D	DO43434	UCEC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	0.1111
p.E145Q	DO230961	LUSC	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	0.1667
p.T129I	DO222843	MELA	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	0.2778
p.E126D	DO229259	THCA	ICGC	SRVRLLVLV	DEG_APCC_DBOX_1	0.1944
p.P144A	SIDM00194	Colorectal Carcinoma	GDSC	SRVRLLVLV	DEG_APCC_DBOX_1	0.1944
p.P144A	SIDM00437	Acute Myeloid Leukemia	GDSC	SRVRLLVLV	DEG_APCC_DBOX_1	0.1944
p.P144A	SIDM00054	Pancreatic Carcinoma	GDSC	SRVRLLVLV	DEG_APCC_DBOX_1	0.1944
p.R134C	SIDM01664	Prostate Carcinoma	GDSC	SRVRLLVLV	DEG_APCC_DBOX_1	0.719
p.R134C	ACH-000952	Prostate Cancer	CCLE	SRVRLLVLV	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99795	Cell surface A33 antigen	DEG_APCC_DBOX_1	131:139	SRVRLLVLV	APC,CDC20,FZR1	0.6005	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons