DegronMD - Q9NQV6(PRDM10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q925K	TCGA-91-6828	LUAD	TCGA	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.0556
p.A861T	TCGA-BG-A2L7	UCEC	TCGA	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.1667
p.R923I	TCGA-CA-6718	COAD	TCGA	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.1111
p.V882A	TCGA-CK-4951	COAD	TCGA	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.0833
p.R915Q	TCGA-ND-A4WC	UCS	TCGA	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	SIDM00993	Plasma Cell Myeloma	GDSC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	SIDM01040	Ovarian Carcinoma	GDSC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	SIDM00370	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	SIDM00463	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	SIDM00296	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	SIDM00024	Non-Cancerous	GDSC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	SIDM00324	Neuroblastoma	GDSC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	SIDM00368	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	LU-134-A	lung	COSMIC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	AMO-1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	TGW	autonomic ganglia	COSMIC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	SBC-5	lung	COSMIC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	TALL-1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.R915Q	FU-OV-1	ovary	COSMIC	DYR	CBL_MET	913:915	Mutation altering degron motif	0.7329
p.T869I	TCGA-P5-A780	LGG	TCGA	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation altering degron motif	0.7078
p.H870D	DO224989	BRCA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation altering degron motif	0.7688
p.S863C	DO223129	ESCA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.2222
p.P869S	DO233113	GACA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation altering degron motif	0.6752
p.L878I	DO229032	LICA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.1944
p.S868T	DO232641	PBCA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation altering degron motif	0.7116
p.Q912H	DO37901	SKCM	ICGC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.3056
p.S868F	DO51270	SKCM	ICGC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation altering degron motif	0.7982
p.A911T	DO40879	UCEC	ICGC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2778
p.R919C	DO41871	UCEC	ICGC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2222
p.R919C	DO42793	UCEC	ICGC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2222
p.S864F	SIDM00969	Ovarian Carcinoma	GDSC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.25
p.S864F	DOV13	ovary	COSMIC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.25
p.T880S	ACH-000966	Ovarian Cancer	CCLE	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.1389
p.T880S	IGROV-1	ovary	COSMIC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.1389
p.R911Q	LU-134-A	lung	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2778
p.R911Q	TGW	autonomic ganglia	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2778
p.R911Q	FU-OV-1	ovary	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2778
p.R911Q	TALL-1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2778
p.R911Q	AMO-1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2778
p.R911Q	SBC-5	lung	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2778
p.R911Q	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2778
p.R919H	SNU-175	large intestine	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.2222
p.Q912K	G-MEL	skin	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.3056
p.V879A	SCC-9	upper aerodigestive tract	COSMIC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.1667
p.S906L	COLO-680N	oesophagus	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.1389
p.S860F	DOV13	ovary	COSMIC	IHTPLTT	DEG_SCF_FBW7_1	867:873	Mutation rewiring degron network	0.1389
p.A905T	C-33-A	cervix	COSMIC	DYR	CBL_MET	913:915	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRDM10

UniProt ID: Q9NQV6

Entrez ID: 56980

Protein name: PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRDM10 in