DegronMD

Uniprot ID: Q9NQV6

Source protein: PR domain zinc finger protein 10

Source gene: PRDM10

Class: DEG_SCF_FBW7_1

Location: 867:873

E3 ligase: FBXW7

DEGRON score: 0.5927

ASA_SCORE: 65.4714

COIL: 0.6266

CONS_SCORE: 0.3752

DSS_SCORE: 0.2988

HELIX: 0.0446

FCONS_SCORE: 0.7286

RIG_SCORE: 0.7962

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S868F	DO51270	SKCM	ICGC	IHTPLTT	DEG_SCF_FBW7_1	0.7982
p.H870D	DO224989	BRCA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	0.7688
p.S868T	DO232641	PBCA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	0.7116
p.T869I	TCGA-P5-A780	LGG	TCGA	IHTPLTT	DEG_SCF_FBW7_1	0.7078
p.P869S	DO233113	GACA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	0.6752
p.S864F	SIDM00969	Ovarian Carcinoma	GDSC	IHTPLTT	DEG_SCF_FBW7_1	0.25
p.S864F	DOV13	ovary	COSMIC	IHTPLTT	DEG_SCF_FBW7_1	0.25
p.S863C	DO223129	ESCA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	0.2222
p.L878I	DO229032	LICA	ICGC	IHTPLTT	DEG_SCF_FBW7_1	0.1944
p.A861T	TCGA-BG-A2L7	UCEC	TCGA	IHTPLTT	DEG_SCF_FBW7_1	0.1667
p.V879A	SCC-9	upper_aerodigestive_tract	COSMIC	IHTPLTT	DEG_SCF_FBW7_1	0.1667
p.T880S	ACH-000966	Ovarian Cancer	CCLE	IHTPLTT	DEG_SCF_FBW7_1	0.1389
p.T880S	IGROV-1	ovary	COSMIC	IHTPLTT	DEG_SCF_FBW7_1	0.1389
p.S860F	DOV13	ovary	COSMIC	IHTPLTT	DEG_SCF_FBW7_1	0.1389
p.V882A	TCGA-CK-4951	COAD	TCGA	IHTPLTT	DEG_SCF_FBW7_1	0.0833

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQV6	PR domain zinc finger protein 10	DEG_SCF_FBW7_1	867:873	IHTPLTT	FBXW7	0.5927	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons