DegronMD - Q92804(TAF15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R590Q	TCGA-AP-A0LM	UCEC	TCGA	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.1667
p.R590Q	TCGA-AP-A1E0	UCEC	TCGA	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.1667
p.Y83H	TCGA-AX-A06F	UCEC	TCGA	NQKQSSYSQQP	CBL_PTK	72:82	Mutation blocking phosphorylation signal	0.75
p.P82T	TCGA-AX-A1CE	UCEC	TCGA	NQKQSSYSQQP	CBL_PTK	72:82	Mutation altering degron motif	0.7031
p.S66F	TCGA-B5-A11N	UCEC	TCGA	NQKQSSYSQQP	CBL_PTK	72:82	Mutation rewiring degron network	0.1667
p.R588H	TCGA-DU-6392	LGG	TCGA	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.2222
p.R588H	TCGA-HU-A4GT	STAD	TCGA	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.2222
p.R584S	TCGA-UC-A7PF	CESC	TCGA	DYR	CBL_MET	582:584	Mutation altering degron motif	0.7427
p.R585C	DO229389	BTCA	ICGC	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.3056
p.R581S	DO49987	CESC	ICGC	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.3056
p.D579N	DO222492	COCA	ICGC	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.25
p.R585H	DO22237	LGG	ICGC	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.3056
p.R585H	DO228138	PBCA	ICGC	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.3056
p.R585H	DO48020	STAD	ICGC	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.3056
p.S73I	DO228850	LICA	ICGC	NQKQSSYSQQP	CBL_PTK	72:82	Mutation altering degron motif	0.7341
p.N81D	DO222354	LICA	ICGC	NQKQSSYSQQP	CBL_PTK	72:82	Mutation altering degron motif	0.6932
p.R587Q	DO43306	UCEC	ICGC	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.25
p.R587Q	DO43154	UCEC	ICGC	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.25
p.P79T	DO42280	UCEC	ICGC	NQKQSSYSQQP	CBL_PTK	72:82	Mutation altering degron motif	0.7031
p.Y80H	DO41752	UCEC	ICGC	NQKQSSYSQQP	CBL_PTK	72:82	Mutation altering degron motif	0.7229
p.S63F	DO41458	UCEC	ICGC	NQKQSSYSQQP	CBL_PTK	72:82	Mutation rewiring degron network	0.0833
p.R588C	SIDM00680	Colorectal Carcinoma	GDSC	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.2222
p.R588C	ACH-000957	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	582:584	Mutation rewiring degron network	0.2222
p.Y67C	SIDM00375	Head and Neck Carcinoma	GDSC	NQKQSSYSQQP	CBL_PTK	72:82	Mutation rewiring degron network	0.1944
p.Y67C	ACH-002305	Head and Neck Cancer	CCLE	NQKQSSYSQQP	CBL_PTK	72:82	Mutation rewiring degron network	0.1944
p.Q73E	SIDM00528	Breast Carcinoma	GDSC	NQKQSSYSQQP	CBL_PTK	72:82	Mutation altering degron motif	0.5633

Kaplan plot for TAF15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF15

UniProt ID: Q92804

Entrez ID: 8148

Protein name: TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAF15 in