DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
NQKQSSYSQQP
Uniprot ID:
Q92804
Source protein:
TATA-binding protein-associated factor 2N
Source gene:
TAF15
Class:
CBL_PTK
Location:
72:82
E3 ligase:
CBL
DEGRON score:
0.9976
ASA_SCORE:
73.6636
COIL:
0.8507
CONS_SCORE:
0.3466
DSS_SCORE:
0.6949
HELIX:
0.0752
FCONS_SCORE:
1.0273
RIG_SCORE:
0.6596
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y83H
TCGA-AX-A06F
UCEC
TCGA
NQKQSSYSQQP
CBL_PTK
0.75
p.P82T
TCGA-AX-A1CE
UCEC
TCGA
NQKQSSYSQQP
CBL_PTK
0.7031
p.S66F
TCGA-B5-A11N
UCEC
TCGA
NQKQSSYSQQP
CBL_PTK
0.1667
p.S73I
DO228850
LICA
ICGC
NQKQSSYSQQP
CBL_PTK
0.7341
p.N81D
DO222354
LICA
ICGC
NQKQSSYSQQP
CBL_PTK
0.6932
p.P79T
DO42280
UCEC
ICGC
NQKQSSYSQQP
CBL_PTK
0.7031
p.Y80H
DO41752
UCEC
ICGC
NQKQSSYSQQP
CBL_PTK
0.7229
p.S63F
DO41458
UCEC
ICGC
NQKQSSYSQQP
CBL_PTK
0.0833
p.Y67C
SIDM00375
Head and Neck Carcinoma
GDSC
NQKQSSYSQQP
CBL_PTK
0.1944
p.Y67C
ACH-002305
Head and Neck Cancer
CCLE
NQKQSSYSQQP
CBL_PTK
0.1944
p.Q73E
SIDM00528
Breast Carcinoma
GDSC
NQKQSSYSQQP
CBL_PTK
0.5633
Drug responses associated with TAF15 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NQKQSSYSQQP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92804
TATA-binding protein-associated factor 2N
CBL_PTK
72:82
NQKQSSYSQQP
CBL
0.9976
More...
