DegronMD - P40424(PBX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T328A	TCGA-22-5474	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.L346F	TCGA-39-5024	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.0556
p.S343C	TCGA-64-5781	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1389
p.T163M	TCGA-B9-A5W8	KIRP	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.1944
p.D149V	TCGA-C8-A8HP	BRCA	TCGA	DYR	CBL_MET	149:151	Mutation altering degron motif	0.7785
p.D149N	TCGA-D3-A2JH	SKCM	TCGA	DYR	CBL_MET	149:151	Mutation altering degron motif	0.6932
p.A152G	TCGA-D3-A5GU	SKCM	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6429
p.L346V	TCGA-E6-A1LX	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.0556
p.H162Y	TCGA-EE-A2M5	SKCM	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.2222
p.F338C	TCGA-EJ-5507	PRAD	TCGA	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.P329S	TCGA-EO-A22R	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.25
p.Q159H	TCGA-EO-A3AV	UCEC	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.3056
p.Q159H	TCGA-EO-A3AV	UCEC	TCGA	DYR	CBL_MET	149:151	Mutation rewiring degron network	0.1111
p.G140C	TCGA-IB-7651	PAAD	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.0556
p.G140C	TCGA-IB-7651	PAAD	TCGA	DYR	CBL_MET	149:151	Mutation rewiring degron network	0.0833
p.N153Y	DO4134	BRCA	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.7059
p.P154A	DO229333	BTCA	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.7503
p.Y335H	DO7798	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation altering degron motif	0.7229
p.D343N	DO22295	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1389
p.E162D	DO26590	LUSC	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.2222
p.S157G	DO219136	LUSC	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6993
p.Y155F	DO228305	MALY	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.7528
p.Y155C	DO38795	STAD	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.7087
p.L151F	DO43186	UCEC	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6981
p.L151F	DO43186	UCEC	ICGC	DYR	CBL_MET	149:151	Mutation altering degron motif	0.6981
p.S343Y	SIDM00455	Pancreatic Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1389
p.S343Y	PA-TU-8902	pancreas	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1389
p.S343T	SIDM00455	Pancreatic Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1389
p.S343T	PA-TU-8902	pancreas	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1389
p.D149H	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	149:151	Mutation altering degron motif	0.7688
p.D149H	ACH-001363	Lung Cancer	CCLE	DYR	CBL_MET	149:151	Mutation altering degron motif	0.7688
p.D149H	NCI-H2135	lung	COSMIC	DYR	CBL_MET	149:151	Mutation altering degron motif	0.7688
p.S325L	SIDM01017	B-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation blocking phosphorylation signal	0.5833
p.S325L	ACH-002255	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation blocking phosphorylation signal	0.5833
p.S325L	KARPAS-231	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation blocking phosphorylation signal	0.5833
p.M340V	SIDM00505	Pancreatic Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.M340V	ACH-000601	Pancreatic Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.M340V	MIA-PaCa-2	pancreas	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.S343N	ACH-000599	Pancreatic Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1389
p.H334D	ACH-000763	Myeloma	CCLE	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation altering degron motif	0.7688
p.H334D	MM1S	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation altering degron motif	0.7688
p.G331C	ACH-000945	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.3056
p.G331C	NCI-H650	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.3056
p.T327A	ACH-000951	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1944
p.T327A	NCI-H2342	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1944
p.V323L	ACH-000958	Colon/Colorectal Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.0833
p.V323L	SW48	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.0833
p.H337D	MM1S	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.3056
p.T330A	NCI-H2342	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.E162V	A2780	ovary	COSMIC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.2222
p.V326L	SW48	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1667
p.R150W	PF-382	haematopoietic and lymphoid tissue	COSMIC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.8634
p.R150W	PF-382	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	149:151	Mutation altering degron motif	0.8634
p.G334C	NCI-H650	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	332:336	Mutation altering degron motif	0.76
p.E145V	A2780	ovary	COSMIC	YRAKLSQIR	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.1944
p.E145V	A2780	ovary	COSMIC	DYR	CBL_MET	149:151	Mutation rewiring degron network	0.2222

Kaplan plot for PBX1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PBX1

UniProt ID: P40424

Entrez ID: 5087

Protein name: Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PBX1 in