DegronMD

Uniprot ID: P40424

Source protein: Pre-B-cell leukemia transcription factor 1

Source gene: PBX1

Class: DEG_APCC_DBOX_1

Location: 150:158

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8262

ASA_SCORE: 53.0444

COIL: 0.0152

CONS_SCORE: 0.4824

DSS_SCORE: 0.3434

HELIX: 0.9831

FCONS_SCORE: 1.0605

RIG_SCORE: 0.7744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T163M	TCGA-B9-A5W8	KIRP	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	0.1944
p.A152G	TCGA-D3-A5GU	SKCM	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	0.6429
p.H162Y	TCGA-EE-A2M5	SKCM	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	0.2222
p.Q159H	TCGA-EO-A3AV	UCEC	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	0.3056
p.G140C	TCGA-IB-7651	PAAD	TCGA	YRAKLSQIR	DEG_APCC_DBOX_1	0.0556
p.N153Y	DO4134	BRCA	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	0.7059
p.P154A	DO229333	BTCA	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	0.7503
p.E162D	DO26590	LUSC	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	0.2222
p.S157G	DO219136	LUSC	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	0.6993
p.Y155F	DO228305	MALY	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	0.7528
p.Y155C	DO38795	STAD	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	0.7087
p.L151F	DO43186	UCEC	ICGC	YRAKLSQIR	DEG_APCC_DBOX_1	0.6981
p.E162V	A2780	ovary	COSMIC	YRAKLSQIR	DEG_APCC_DBOX_1	0.2222
p.R150W	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	YRAKLSQIR	DEG_APCC_DBOX_1	0.8634
p.E145V	A2780	ovary	COSMIC	YRAKLSQIR	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40424	Pre-B-cell leukemia transcription factor 1	DEG_APCC_DBOX_1	150:158	YRAKLSQIR	APC,CDC20,FZR1	0.8262	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons