DegronMD - Q9Y5G2(PCDHGB2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L356I	TCGA-17-Z031	LUAD	TCGA	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation altering degron motif	0.6063
p.G363E	TCGA-22-5480	LUSC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.1944
p.G363E	DO26786	LUSC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.1944
p.D342A	TCGA-27-1837	GBM	TCGA	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.0556
p.D342A	DO12010	GBM	ICGC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.0556
p.D444N	TCGA-AG-3892	READ	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444N	DO222492	COCA	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444N	DO36394	READ	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444N	SIDM00569	Osteosarcoma	GDSC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444N	SIDM00193	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444N	SIDM00008	Ovarian Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444N	SIDM01447	Glioblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444N	NY	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444N	SNU-81	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.P430S	TCGA-AP-A059	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.3056
p.P430S	DO41361	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.3056
p.H441Y	TCGA-B5-A1MX	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1667
p.H441Y	DO41999	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1667
p.S360L	TCGA-B5-A3FA	UCEC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.2778
p.S360L	DO52402	UCEC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.2778
p.D342N	TCGA-B5-A3S1	UCEC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.0556
p.D342N	DO41277	UCEC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.0556
p.E358D	TCGA-BS-A0UF	UCEC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation altering degron motif	0.6758
p.E358D	DO41488	UCEC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation altering degron motif	0.6758
p.S353P	TCGA-BS-A0UV	UCEC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation altering degron motif	0.5641
p.S353P	DO42793	UCEC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation altering degron motif	0.5641
p.A424S	TCGA-CM-6677	COAD	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1389
p.A424S	DO8570	COAD	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1389
p.S434F	TCGA-D3-A2JH	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.7982
p.S434F	DO47263	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.7982
p.T421I	TCGA-D9-A6EC	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.T421I	DO50291	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.S435G	TCGA-E2-A15E	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.6993
p.S435G	DO2629	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.6993
p.P355S	TCGA-FW-A3R5	SKCM	TCGA	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation altering degron motif	0.6752
p.P355S	DO37406	SKCM	ICGC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation altering degron motif	0.6752
p.T421S	TCGA-G4-6302	COAD	TCGA	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.T421S	DO8778	COAD	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.D342E	DO230329	COCA	ICGC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.0556
p.P897T	DO233115	GACA	ICGC	DYR	CBL_MET	889:891	Mutation rewiring degron network	0.1667
p.L432V	DO231819	LINC	ICGC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.5654
p.V887M	DO25554	LUAD	ICGC	DYR	CBL_MET	889:891	Mutation rewiring degron network	0.2778
p.V887M	SLVL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	889:891	Mutation rewiring degron network	0.2778
p.V894G	DO28089	OV	ICGC	DYR	CBL_MET	889:891	Mutation rewiring degron network	0.25
p.T883A	DO48918	PBCA	ICGC	DYR	CBL_MET	889:891	Mutation rewiring degron network	0.1667
p.R891H	DO41871	UCEC	ICGC	DYR	CBL_MET	889:891	Mutation altering degron motif	0.8244
p.R891C	DO42568	UCEC	ICGC	DYR	CBL_MET	889:891	Mutation altering degron motif	0.8301
p.I436V	SIDM00584	Osteosarcoma	GDSC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.3056
p.I436V	ACH-002142	Bone Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.3056
p.I436V	HuO-3N1	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.3056
p.S351L	SIDM01174	Cervical Carcinoma	GDSC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.3056
p.S351L	ACH-001402	Cervical Cancer	CCLE	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.3056
p.S351L	SW756	cervix	COSMIC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.3056
p.A344V	SIDM00683	Prostate Carcinoma	GDSC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.1111
p.A344V	ACH-000977	lymph node	CCLE	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.1111
p.A344V	LNCaP-Clone-FGC	prostate	COSMIC	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.1111
p.D444Y	SIDM00999	Bladder Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444Y	ACH-000973	Bladder Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.D444Y	639-V	urinary tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.P362Q	ACH-002800	Unknown	CCLE	VSTPLPE	DEG_SCF_FBW7_2	352:358	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGB2

UniProt ID: Q9Y5G2

Entrez ID: 56103

Protein name: Protocadherin gamma-B2 (PCDH-gamma-B2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PCDHGB2 in